- 专利标题: COMPOUND FOR THE SEQUESTRATION OF UNDESIRABLE ANTIBODIES IN A PATIENT
-
申请号: EP21187621.4申请日: 2020-03-23
-
公开(公告)号: EP3960769A1公开(公告)日: 2022-03-02
- 发明人: SMRZKA, Oskar , WANKO, Bettina
- 申请人: Ablevia biotech GmbH
- 申请人地址: AT 1030 Vienna Maria-Jacobi-Gasse 1
- 代理机构: SONN Patentanwälte OG
- 优先权: EP19164784 20190323
- 主分类号: C07K17/06
- IPC分类号: C07K17/06 ; A61K39/00 ; A61K47/54 ; C07K14/05
摘要:
The present invention provides a compound for the sequestration of undesirable antibodies (e.g. related to an autoimmune disease) in a patient. The compound comprises an inert biopolymer scaffold and at least a first peptide n-mer of the general formula P ( ― S — P ) (n-1) and a second peptide n-mer of the general formula P ( — S — P )(n-1) ; wherein, independently for each occurrence, P is a peptide with a sequence length of 2-13 amino acids and S is a non-peptide spacer, wherein, independently for each of the peptide n-mers, n is an integer of at least 1, wherein each of the peptide n-mers is bound to the biopolymer scaffold. Also provided are pharmaceutical compositions comprising the compound, as well as a method of sequestering one or more antibodies present in an individual and a method of inhibiting an immune reaction to a treatment with an active agent.
信息查询