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    COMPOUND FOR THE SEQUESTRATION OF UNDESIRABLE ANTIBODIES IN A PATIENT
    2.
    发明公开
    COMPOUND FOR THE SEQUESTRATION OF UNDESIRABLE ANTIBODIES IN A PATIENT 审中-公开

    公开(公告)号：EP3960769A1

    公开(公告)日：2022-03-02

    申请号：EP21187621.4

    申请日：2020-03-23

    申请人： Ablevia biotech GmbH

    发明人： SMRZKA, Oskar ,  WANKO, Bettina

    IPC分类号： C07K17/06 ,  A61K39/00 ,  A61K47/54 ,  C07K14/05

    摘要： The present invention provides a compound for the sequestration of undesirable antibodies (e.g. related to an autoimmune disease) in a patient. The compound comprises an inert biopolymer scaffold and at least a first peptide n-mer of the general formula P ( ― S — P ) (n-1) and a second peptide n-mer of the general formula P ( — S — P )(n-1) ; wherein, independently for each occurrence, P is a peptide with a sequence length of 2-13 amino acids and S is a non-peptide spacer, wherein, independently for each of the peptide n-mers, n is an integer of at least 1, wherein each of the peptide n-mers is bound to the biopolymer scaffold. Also provided are pharmaceutical compositions comprising the compound, as well as a method of sequestering one or more antibodies present in an individual and a method of inhibiting an immune reaction to a treatment with an active agent.