A sole structure (200) for an article of footwear having an upper (10) includes a heel region (16), a forefoot region (12), and a mid-foot region(14) disposed between the heel region and the forefoot region. It comprises a first chamber including (i) a first segment (218) having a medial reservoir (224) defining a prolate hemispheroid shape including a major axis (30) extending along a medial side (20) of the sole structure (200) and (ii) a second segment (218) having a lateral reservoir (220) defining a prolate hemispheroid shape including a major axis (30) extending along a lateral side (18) of the sole structure (200).