- 专利标题： NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS
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申请号： EP21199207.8申请日： 2016-08-25
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公开(公告)号： EP3974428A1公开(公告)日： 2022-03-30
- 发明人: WU, Tongfei , BREHMER, Dirk , BEKE, Lijs , BOECKX, An , DIELS, Gaston Stanislas Marcella , GILISSEN, Ronaldus Arnodus Hendrika Joseph , LAWSON, Edward Charles , PANDE, Vineet , PARADE, Marcus Cornelis Bernardus Catharina , SCHEPENS, Wim Bert Griet , THURING, Johannes Wilhelmus John F. , VIELLEVOYE, Marcel , SUN, Weimei , MEERPOEL, Lieven
- 申请人： Janssen Pharmaceutica NV
- 申请人地址： BE 2340 Beerse Turnhoutseweg 30
- 代理机构： Lenaerts, Philip
- 优先权： US201662306233 P 20160310
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/519 ; A61K31/53
摘要：
The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)
wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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