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公开(公告)号：EP4385996A3
公开(公告)日：2024-07-31
申请号：EP24162318.0
申请日：2018-12-06
发明人： VERHOEVEN, Jonas , VERNIEST, Guido Alfons F. , THURING, Johannes Wilhelmus John F. , WU, Tongfei , PANDE, Vineet , MEERPOEL, Lieven , BREHMER, Dirk , SUN, Weimei , DENMARK, Scott E.
IPC分类号： C07H19/14 , C07D471/04 , A61K31/505 , A61P35/00
CPC分类号： C07D307/94 , C07D317/44 , C07H19/14 , C07D471/04 , A61P35/00 , C07H19/167
摘要： The present invention relates to novel spirobicyclic analogues of Formula (I)
wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.-
公开(公告)号：EP4347600A1
公开(公告)日：2024-04-10
申请号：EP22729426.1
申请日：2022-06-02
发明人： CAI, Wei , DAI, Xuedong , QUEROLLE, Olivier, Alexis, Georges , THURING, Johannes, Wilhelmus, J. , DENG, Xiangjun , FANG, Lichao , FU, Liqiang , LI, Ming , LIU, Lianzhu , LIU, Yingtao , XU, Yanping , PANDE, Vineet
IPC分类号： C07D487/10 , A61P3/10 , A61P35/00 , A61K31/53
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公开(公告)号：EP3512858A1
公开(公告)日：2019-07-24
申请号：EP17768750.6
申请日：2017-09-13
发明人： ANGIBAUD, Patrick, René , PANDE, Vineet , HERKERT, Barbara , KROSKY, Daniel, Jason , QUEROLLE, Olivier, Alexis, Georges , PATRICK, Aaron Nathaniel
IPC分类号： C07D519/04 , A61P35/00 , A61P3/10
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公开(公告)号：EP4355747A1
公开(公告)日：2024-04-24
申请号：EP22733288.9
申请日：2022-06-16
发明人： CAI, Wei , DAI, Xuedong , QUEROLLE, Olivier Alexis Georges , THURING, Johannes Wilhelmus J. , NG, Alicia Tee Fuay , DARVILLE, Nicolas Freddy Jacques Bruno , GEERTMAN, Robert Michael , AHUJA, Dipali , LIU, Yingtao , PANDE, Vineet , CLEATOR, Edward , BEN HAIM, Cyril , SMOLDERS, Simon Jan C
IPC分类号： C07D487/04 , A61P35/00 , A61K31/53 , C07C1/00 , C07D487/10
CPC分类号： C07D487/10 , A61P35/00 , C07C231/02
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公开(公告)号：EP4347588A1
公开(公告)日：2024-04-10
申请号：EP22729029.3
申请日：2022-05-30
发明人： CAI, Wei , THURING, Johannes Wilhelmus J. , HULPIA, Fabian , DAI, Xuedong , LI, Ming , DENG, Xiangjun , LIANG, Chao , NG, Alicia Tee Fuay , SUN, Zhen , ZHANG, Zhigao , DEMIN, Samuël Dominique , DYUBANKOVA, Natalia Nikolaevna , JOUFFROY, Matthieu, Dominique , LEPRI, Susan , DARVILLE, Nicolas Freddy Jacques Bruno , PANDE, Vineet , SCHEPENS, Wim Bert Griet , EDWARDS, James Patrick , QUEROLLE, Olivier Alexis Georges
IPC分类号： C07D471/04 , C07D487/04 , A61P35/00
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公开(公告)号：EP4334310A1
公开(公告)日：2024-03-13
申请号：EP22725155.0
申请日：2022-05-06
发明人： QUEROLLE, Olivier Alexis Georges , DAI, Xuedong , CAI, Wei , THURING, Johannes Wilhelmus J. , FANG, Lichao , LI, Ming , LIU, Lianzhu , LIU, Yingtao , QIN, Luoheng , WU, Jianping , XU, Yanping , ANGIBAUD, Patrick René , COLOMBEL, Hélène France Solange , PILATTE, Isabelle Noëlle Constance , PONCELET, Virginie Sophie , KRAMER, Carsten Sven , PANDE, Vineet
IPC分类号： C07D405/14 , C07D471/10 , C07D487/10 , A61P35/00 , A61P35/02 , A61P3/10 , A61K31/53 , A61K31/407
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7.发明公开
公开(公告)号：EP4219496A1
公开(公告)日：2023-08-02
申请号：EP23162887.6
申请日：2016-08-25
发明人： WU, Tongfei , BREHMER, Dirk , BEKE, Lijs , BOECKX, An , DIELS, Gaston, Stanislas, Marcella , GILISSEN, Ronaldus, Arnodus, Hendrika, Joseph , LAWSON, Edward, Charles , PANDE, Vineet , PARADE, Marcus, Cornelis, Bernardus, Catharina , SCHEPENS, Wim, Bert, Griet , THURING, Johannes, Wilhelmus, John, F. , VIELLEVOYE, Marcel , SUN, Weimei , MEERPOEL, Lieven
IPC分类号： C07D471/04 , A61K31/519 , A61K31/53
摘要： The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)
wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.-
公开(公告)号：EP3512857A1
公开(公告)日：2019-07-24
申请号：EP17768428.9
申请日：2017-09-13
发明人： ANGIBAUD, Patrick, René , PANDE, Vineet , HERKERT, Barbara , KROSKY, Daniel, Jason , QUEROLLE, Olivier, Alexis, Georges , PILATTE, Isabelle, Noëlle, Constance , PATRICK, Aaron, Nathaniel
IPC分类号： C07D519/00 , A61K45/06 , A61P35/00
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9.发明公开
公开(公告)号：EP3341368A1
公开(公告)日：2018-07-04
申请号：EP16757233.8
申请日：2016-08-25
发明人： WU, Tongfei , BREHMER, Dirk , BEKE, Lijs , BOECKX, An , DIELS, Gaston, Stanislas, Marcella , GILISSEN, Ronaldus, Arnodus, Hendrika, Joseph , LAWSON, Edward, Charles , PANDE, Vineet , PARADE, Marcus, Cornelis, Bernardus, Catharina , SCHEPENS, Wim, Bert, Griet , THURING, Johannes, Wilhelmus, John, F , VIELLEVOYE, Marcel , SUN, Weimei , MEERPOEL, Lieven
IPC分类号： C07D471/04 , A61K31/519 , A61K31/53
CPC分类号： A61K31/7076 , A61K31/5025 , A61K31/519 , A61K31/53 , A61P35/00 , C07D471/04
摘要： wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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公开(公告)号：EP4385996A2
公开(公告)日：2024-06-19
申请号：EP24162318.0
申请日：2018-12-06
发明人： VERHOEVEN, Jonas , VERNIEST, Guido Alfons F. , THURING, Johannes Wilhelmus John F. , WU, Tongfei , PANDE, Vineet , MEERPOEL, Lieven , BREHMER, Dirk , SUN, Weimei , DENMARK, Scott E.
IPC分类号： C07H19/167
CPC分类号： C07D307/94 , C07D317/44 , C07H19/14 , C07D471/04 , A61P35/00 , C07H19/167
摘要： The present invention relates to novel spirobicyclic analogues of Formula (I)
wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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