发明公开
- 专利标题： METHODS AND COMPOSITIONS USEFUL IN GENERAING NON CANONICAL CD8+T CELL RESPONSES
-
申请号： EP21205026.4申请日： 2016-02-10
-
公开(公告)号： EP4036239A1公开(公告)日： 2022-08-03
- 发明人: FRUEH, Klaus , PICKER, Louis , HANSEN, Scott , SACHA, Jonah , MALOULI, Daniel
- 申请人： Oregon Health & Science University
- 申请人地址： US Portland, OR 97239 0690 SW Bancroft St.
- 代理机构： Predazzi, Valentina
- 优先权： US201562220703 P 20150918
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C12N15/12 ; C12N15/33 ; C07K14/705 ; C07K14/725 ; C12N5/0783 ; C12Q1/68 ; A61K48/00 ; A61P35/00
摘要：
Methods of inducing a CD8+ T celi response to a heterologous antigen in which at least 10% of the CD8+ T cells are
MHC-E restricted are disclosed. The method involves immunizing with a CMV vector that does not express UL128 and UL130 pro- teins. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, a UL40 pro- tein, and a US28 protein but that do not express an active UL128 and UL130 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active UL40 protein, UL128 protein, UL130 protein, and optionally a US28 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active US28 protein, UL128 protein, UL130 protein, and optionally a UL40 protein.
MHC-E restricted are disclosed. The method involves immunizing with a CMV vector that does not express UL128 and UL130 pro- teins. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, a UL40 pro- tein, and a US28 protein but that do not express an active UL128 and UL130 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active UL40 protein, UL128 protein, UL130 protein, and optionally a US28 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active US28 protein, UL128 protein, UL130 protein, and optionally a UL40 protein.
信息查询
IPC分类:
