- 专利标题: METHOD FOR PRODUCING RADIOACTIVE METAL-LABELED ANTIBODY
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申请号: EP20877197.2申请日: 2020-10-16
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公开(公告)号: EP4047010A1公开(公告)日: 2022-08-24
- 发明人: IZAWA, Akihiro , OGAWA, Yu , ICHIKAWA, Hiroaki , KAWATANI, Minoru , TAKEMORI, Hideaki , OKUMURA, Yuki
- 申请人: Nihon Medi-Physics Co., Ltd.
- 申请人地址: JP Tokyo 136-0075 3-4-10 Shinsuna Koto-ku
- 代理机构: J A Kemp LLP
- 优先权: JP2019191561 20191018
- 国际公布: WO2021075546 20210422
- 主分类号: C07K7/08
- IPC分类号: C07K7/08 ; C07K16/00 ; C07K19/00 ; A61K51/10
摘要:
The production method of a radioactive metal-labeled antibody of the present invention includes a step of conducting a click reaction of a radioactive metal complex and an antibody site-specifically modified with a peptide to produce a radioactive metal-labeled antibody. The click reaction is performed between a first atomic group of the radioactive metal complex and a second atomic group directly or indirectly linked to the peptide. The second atomic group is an atomic group containing an azide group, or an atomic group containing trans-cyclooctene.
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