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公开(公告)号：EP4230637A1
公开(公告)日：2023-08-23
申请号：EP21880216.3
申请日：2021-10-15
IPC分类号： C07K1/13 , A61K33/24 , A61K33/244 , A61K39/395 , A61K41/00 , A61K47/68 , A61K47/69 , A61K51/10 , A61P35/00 , C07K7/08 , C07K16/28 , C07K16/30 , C12N15/11
摘要： The present invention provides a conjugate which has stability improved more than conventional conjugates without impairing the efficacy. The conjugate of the present invention is a conjugate of an anti-HER2 antibody site-specifically modified with a peptide and a chelating agent, wherein the chelating agent is chelated with a metal radionuclide, the peptide and the chelating agent are linked by a linker (L), and the linker (L) does not contain a thiourea bond.
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公开(公告)号：EP4047010A1
公开(公告)日：2022-08-24
申请号：EP20877197.2
申请日：2020-10-16
发明人： IZAWA, Akihiro , OGAWA, Yu , ICHIKAWA, Hiroaki , KAWATANI, Minoru , TAKEMORI, Hideaki , OKUMURA, Yuki
摘要： The production method of a radioactive metal-labeled antibody of the present invention includes a step of conducting a click reaction of a radioactive metal complex and an antibody site-specifically modified with a peptide to produce a radioactive metal-labeled antibody. The click reaction is performed between a first atomic group of the radioactive metal complex and a second atomic group directly or indirectly linked to the peptide. The second atomic group is an atomic group containing an azide group, or an atomic group containing trans-cyclooctene.
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公开(公告)号：EP4317188A1
公开(公告)日：2024-02-07
申请号：EP22781261.7
申请日：2022-03-31
IPC分类号： C07K16/28 , A61K9/08 , A61K9/20 , A61K39/395 , A61K47/42 , A61K47/68 , A61K47/69 , A61K51/02 , A61K51/08 , A61K51/10 , A61P35/00 , C07K7/00 , C07K7/08 , C07K19/00 , C12N15/13 , C12P21/08 , G01T1/161
摘要： A conjugate having stability improved more than conventional conjugates without impairing the efficacy is provided by the present invention. The conjugate of the present invention is a conjugate of an anti-EGFR antibody site-specifically modified with a peptide and a chelating agent, wherein the chelating agent is chelated with a metal radionuclide, the peptide and the chelating agent are linked by a linker (L), and the linker (L) does not contain a thiourea bond.
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公开(公告)号：EP4327831A1
公开(公告)日：2024-02-28
申请号：EP22791751.5
申请日：2022-04-20
IPC分类号： A61K47/68 , A61K39/395 , A61K45/00 , A61K47/60 , A61K47/69 , A61K51/00 , A61K51/02 , A61K51/10 , A61P35/00 , C07K4/00 , C07K16/28
摘要： The present invention aims to provide a conjugate having stability improved more than conventional conjugates without impairing the efficacy. The conjugate of the present invention is a conjugate of an anti-CD20 antibody and a chelating agent, wherein the chelating agent is chelated with a metal radionuclide, the anti-CD20 antibody and the chelating agent are linked by a linker (L), and the linker (L) does not contain a thiourea bond.
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公开(公告)号：EP4397320A1
公开(公告)日：2024-07-10
申请号：EP22864604.8
申请日：2022-08-31
发明人： KISHIMOTO, Satoshi , TAKEDA, Takuya , NARITA, Yudai , KAWATANI, Minoru , IZAWA, Akihiro , TARUMIZU, Yuta
摘要： The present invention provides "a conjugate of a chelating agent chelated with a radionuclide and a deglycosylated antibody, wherein the chelating agent site-specifically modifies the Fc region of the aforementioned antibody via a linker". The conjugate is improved in the risk of a decrease in the effect and the risk of side effects.
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公开(公告)号：EP4234540A1
公开(公告)日：2023-08-30
申请号：EP21882711.1
申请日：2021-10-14
摘要： The present invention pertains to a method that is for producing a radioactive zirconium labelled complex and that can achieve a high labelling rate in a reaction between a ligand compound and radioactive zirconium ions. The production method according to the present invention comprises a step for causing a reaction between a ligand compound and radioactive zirconium ions in a reaction solution containing water to cause coordination of the radioactive zirconium ions. Said step is performed in a state where the pH of the reaction solution is in an acidic range. The reaction solution does not contain an organic solvent but contains, apart from the ligand compound, a water-soluble organic compound that has, in the structure, one or two sulfo groups or carboxy groups.
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