- 专利标题: AQUEOUS PHARMACEUTICAL COMPOSITION CONTAINING FUSION PROTEIN OF SERUM ALBUMIN AND GROWTH HORMONE
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申请号: EP20881312.1申请日: 2020-10-29
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公开(公告)号: EP4059512A1公开(公告)日: 2022-09-21
- 发明人: OKABE, Shinji , YAMAGUCHI, Yuka , YASUKAWA, Hidehito
- 申请人: JCR Pharmaceuticals Co., Ltd.
- 申请人地址: JP Ashiya-shi, Hyogo 659-0021 3-19 Kasuga-cho
- 代理机构: Balder IP Law, S.L.
- 优先权: JP2019197978 20191030
- 国际公布: WO2021085518 20210506
- 主分类号: A61K38/27
- IPC分类号: A61K38/27 ; A61K9/08 ; A61K47/04 ; A61K47/10 ; A61K47/26 ; A61K47/64 ; A61P5/06 ; C07K14/61 ; C07K14/765 ; C07K19/00 ; C12N15/14 ; C12N15/18 ; C12N15/62
摘要:
The present invention discloses an aqueous pharmaceutical composition containing a protein in which serum albumin and growth hormone are linked. The aqueous pharmaceutical composition contains, as an active ingredient, a fusion protein of human serum albumin and human growth hormone; the concentration of the fusion protein is 10-100 mg/mL; the concentration of sucrose is 10-150 mg/mL; the concentration of a nonionic surfactant is 0.15-10 mg/mL; the concentration of a preservative is 0.5-12 mg/mL; the concentration of a buffer is 1-30 mM; and the pH is 5.0-8.0.
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