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公开(公告)号：EP4374913A2
公开(公告)日：2024-05-29
申请号：EP24163473.2
申请日：2016-09-08
IPC分类号： A61P5/06
CPC分类号： A61K38/00 , C07K19/00 , C12N5/16 , C12N15/09 , C07K2319/3120130101 , C07K14/765 , A61P43/00 , A61P3/00 , A61P5/06 , C07K14/61
摘要： Disclosed are a human serum albumin mutant consisting of the amino acid sequence set forth as SEQ ID NO:3, as well as a human serum albumin mutant-linked protein (A) comprising a first polypeptide chain comprising the amino acid sequence of the human serum albumin mutant according to claim 1 and a second polypeptide chain linked thereto comprising the amino acid sequence of another protein (A).
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公开(公告)号：EP4218823A2
公开(公告)日：2023-08-02
申请号：EP23164305.7
申请日：2015-11-17
发明人： Kurpiers, Thomas , Rau, Harald , Exner, Evelyn , Jensen, Steen , Rasmussen, Grethe Nørskov , Lessmann, Torben , Wegge, Thomas , Hermann, Alina , Schubert, Nina , Splanemann, Anna , Zettler, Joachim
摘要： The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulations comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.
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公开(公告)号：EP4213869A1
公开(公告)日：2023-07-26
申请号：EP21772845.0
申请日：2021-09-17
申请人： La Marca, Antonio
发明人： La Marca, Antonio
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公开(公告)号：EP3218395B1
公开(公告)日：2022-01-05
申请号：EP15798305.7
申请日：2015-11-12
发明人： BECKERS, Albert , DALY, Adrian Francis , FAUCZ, Fabio Rueda , STRATAKIS, Constantine A. , TRIVELLIN, Giampaolo
IPC分类号： C12N15/113 , C07K16/28 , C07K14/705 , C07K14/72 , A61K38/12 , A61K38/27 , A61K31/48 , A61K31/713 , A61P5/06
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公开(公告)号：EP3892261A1
公开(公告)日：2021-10-13
申请号：EP21162634.6
申请日：2015-11-05
申请人： Ferring B.V.
发明人： HALLIDAY, Janet , CARR, Denis , ROSS, Alistair , YOUNG, Claire , McDONALD, Paul , QADIR, Mohammad , COCHRANE, Robert , RABANI, Gouher , ARCE SAEZ, Joan-Carles , PETRI, Axel Niclas
摘要： The present invention is based on the identification of a cohort of polyurethane block copolymers that are particularly suited for use in pharmaceutical polymeric drug-device units and which offer improved control of drug release. In particular, there is provided a polymeric drug-device unit comprising a polyurethane block copolymer obtainable by reacting together a poly(alkylene oxide); a difunctional compound; a difunctional isocyanate; and optionally a block copolymer comprising poly(alkylene oxide) blocks; and quinagolide as a pharmaceutically active agent. The drug-device units may find application in the treatment and/or prevention of endometriosis.
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公开(公告)号：EP3050576B1
公开(公告)日：2021-03-31
申请号：EP16156852.2
申请日：2009-04-29
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8.发明公开
公开(公告)号：EP3789018A1
公开(公告)日：2021-03-10
申请号：EP19382778.9
申请日：2019-09-09
发明人： RODRIGUEZ DE FONSECA, Fernando , NAVARRO GALERA, Juan Antonio , BAIXERAS LLANOS, Elena , DECARA DEL OLMO, Juan Manuel , MEDINA VERA, Dina , LOPEZ-GAMBERO, Antonio Jesús , SUAREZ PEREZ, Juan , SANJUAN MERINO, Carlos
IPC分类号： A61K31/05 , A61K31/075 , A61P1/16 , A61P3/06 , A61P3/10 , A61P5/06 , A61P9/10 , A61P9/12 , A61P19/02 , A61P19/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61K8/34
摘要： This invention relates to the delivery of a composition, preferably a pharmaceutical composition, comprising D-pinitol, D-Chiro inositol or myo-inositol or any pharmaceutically acceptable salt thereof, for use in the treatment or prevention of disorders, diseases or conditions responsive to the stimulation of the ghrelin receptor in a subject in need thereof. In particular, for the treatment and/or prevention of disorders responsive to the positive modulation (stimulation) of the ghrelin receptor, such as diabetes, obesity-related disorders, and, most preferably, for treating or preventing age related conditions or diseases such as by promoting appetite, inhibiting insulin secretion and lowering insulin resistance, increasing growth hormone release, enhancing muscle vitality or fragility and treating or preventing sarcopenia by increasing net muscle mass, improving cognition (and/or treating or preventing diseases such as Azlheimer's disease, vascular dementia, Parkinson's Disease, and Huntington's disease) and treating or preventing age related hypertension.
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9.发明公开
公开(公告)号：EP3689334A1
公开(公告)日：2020-08-05
申请号：EP20151213.4
申请日：2015-03-11
IPC分类号： A61K9/08 , A61P25/16 , A61P5/06 , A61P25/14 , A61P25/26 , A61P25/28 , A61K31/198 , A61K31/4045 , A61K31/428 , A61K31/506
摘要： Disclosed is a pharmaceutical composition comprising i) a dopamine agonist and ii) a L-DOPA derivative in combination in form of a liquid preparation. The pharmaceutical composition is used for the treatment of Parkinson's disease, restless leg syndrome, dystonia, for inhibiting prolactin secretion, for stimulating the release of growth hormones, for the treatment of neurological symptoms of chronic manganese intoxication, amyotrophic lateral sclerosis, and multiple system atrophy.
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公开(公告)号：EP3495388A1
公开(公告)日：2019-06-12
申请号：EP18203136.9
申请日：2007-09-07
申请人： Amgen Inc.
发明人： HAN, Hq , CHEN, Qing , KWAK, Keith Soo-Nyung , ZHOU, Xiaolan
IPC分类号： C07K16/22 , A61K39/395 , C12N15/13 , A61P5/06 , A61P9/10 , A61P35/00 , A61P37/00 , A61P43/00
摘要： The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.
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