- 专利标题: BETA-LACTAM COMPOUND, USE THEREOF AND PREPARATION METHOD THEREFOR
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申请号: EP21818212.9申请日: 2021-04-30
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公开(公告)号: EP4159733A1公开(公告)日: 2023-04-05
- 发明人: SONG, Danqing , TANG, Sheng , YOU, Xuefu , LI, Zhiwen , WANG, Yanxiang , LU, Xi , LI, Yinghong , HU, Xinxin , GUO, Zhihao , WANG, Xiukun
- 申请人: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences , Guangzhou HC Pharmaceutical Co. Ltd
- 申请人地址: CN Beijing 100050 No.1 Tiantan Xili Dongcheng District; CN Guangzhou, Guangdong 510000 Room 1102, 1103, 1104, 1105, 1201 and 1301 Building C, 288 Shenzhou Road, Huangpu District
- 代理机构: Nederlandsch Octrooibureau
- 优先权: CN202010488264 20200602
- 国际公布: WO2021244199 20211209
- 主分类号: C07D417/12
- IPC分类号: C07D417/12 ; A61K31/427 ; A61K31/433 ; A61P31/04
摘要:
The present invention relates to a compound as shown in general formula (I) below (in formula (I), each of R 1 and R 2 independently represents a hydrogen atom or a C1-10 linear or branched alkyl optionally having a substituent, or the two together form a cycloalkyl with 3 to 8 ring carbon atoms; each of R 3 and R 4 independently represents a hydrogen atom or a C1-10 linear or branched alkyl optionally having a substituent or a C6-12 aryl optionally having a substituent, or the two together form a cycloalky with 3 to 8 ring carbon atoms; X represents C or N; and Y represents a linear or branched alkenyl or alkynyl with 2 to 6 carbon atoms and optionally having a substituent, or carboxyl). The compound has good antibacterial properties against bacteria, especially gram-negative bacteria, has low drug resistance, and has good prospects for the effective treatment of various conditions.
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