- 专利标题： MEDICINE CONTAINING METHEMOGLOBIN ENDOPLASMIC RETICULUM AS ACTIVE INGREDIENT AND USE THEREOF
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申请号： EP21861702.5申请日： 2021-08-27
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公开(公告)号： EP4194005A1公开(公告)日： 2023-06-14
- 发明人: TAGUCHI Kazuaki , SUZUKI Yuto , MATSUMOTO Kazuaki , SAKAI Hiromi , OTAGIRI Masaki
- 申请人： Keio University , Public University Corporation Nara Medical University , Kimigafuchi Gakuen
- 申请人地址： JP Tokyo, 108-8345 15-45, Mita 2-chome, Minato-ku,; JP Nara 634-8521 840 Shijo-cho Kashihara-shi; JP Kumamoto-shi, Kumamoto 860-0082 22-1 Ikeda 4-chome Nishi-ku
- 代理机构： Isarpatent
- 优先权： JP2020144044 20200828
- 国际公布： WO2022045281 20220303
- 主分类号： A61K38/42
- IPC分类号： A61K38/42 ; A61K9/127 ; A61K9/48 ; A61K35/18 ; A61P39/02
摘要：
The present invention is intended to provide a medicament for cyanide poisoning, hydrogen sulfide poisoning, and azide poisoning, wherein the medicament does not cause side effects, is excellent in immediate effectiveness, and has a high antidotal effect. Specifically, the present invention relates to a medicament for cyanide poisoning, hydrogen sulfide poisoning, and azide poisoning, wherein the medicament comprises, as an active ingredient(s), one or more selected from the group consisting of a heme protein capable of binding to cyanide ions (CN - ), hydrogen sulfide ions (HS - ) and azide ions (N 3 - ), a substance containing a heme protein capable of binding to CN - , HS - and N 3 - , and a heme derivative capable of binding to CN - , HS - and N 3 - . More specifically, the present invention relates to a medicament or a pharmaceutical composition for the treatment or prophylaxis of cyanide poisoning, hydrogen sulfide poisoning, and azide poisoning.
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