公开(公告)号：EP4194005A1

公开(公告)日：2023-06-14

申请号：EP21861702.5

申请日：2021-08-27

申请人： Keio University ,  Public University Corporation Nara Medical University ,  Kimigafuchi Gakuen

发明人： TAGUCHI Kazuaki ,  SUZUKI Yuto ,  MATSUMOTO Kazuaki ,  SAKAI Hiromi ,  OTAGIRI Masaki

IPC分类号： A61K38/42 ,  A61K9/127 ,  A61K9/48 ,  A61K35/18 ,  A61P39/02

摘要： The present invention is intended to provide a medicament for cyanide poisoning, hydrogen sulfide poisoning, and azide poisoning, wherein the medicament does not cause side effects, is excellent in immediate effectiveness, and has a high antidotal effect. Specifically, the present invention relates to a medicament for cyanide poisoning, hydrogen sulfide poisoning, and azide poisoning, wherein the medicament comprises, as an active ingredient(s), one or more selected from the group consisting of a heme protein capable of binding to cyanide ions (CN - ), hydrogen sulfide ions (HS - ) and azide ions (N 3 - ), a substance containing a heme protein capable of binding to CN - , HS - and N 3 - , and a heme derivative capable of binding to CN - , HS - and N 3 - . More specifically, the present invention relates to a medicament or a pharmaceutical composition for the treatment or prophylaxis of cyanide poisoning, hydrogen sulfide poisoning, and azide poisoning.