发明公开
- 专利标题： TMEM16A MODULATORS
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申请号： EP22214010.5申请日： 2019-01-25
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公开(公告)号： EP4215520A1公开(公告)日： 2023-07-26
- 发明人: COLLINGWOOD, Stephen , MCCARTHY, Clive , HARGRAVE, Jonathan David , HAY, Duncan Alexander , SCHOFIELD, Thomas Beauregard , ELLAM, Sarah , BUXTON, Craig , HABGOOD, Matthew , INGRAM, Peter , MA, Chun Yan , SHAIKH, Abdul , SMITH, Matthew , STIMSON, Christopher , WALKER, Edward
- 申请人： TMEM16A LIMITED
- 申请人地址： GB Welwyn Garden City, England AL7 1TW 6 Falcon Way Shire Park
- 代理机构： Evans, Sophie Elizabeth
- 优先权： GB201801355 20180126
- 主分类号： C07D213/72
- IPC分类号： C07D213/72 ; C07D309/10 ; C07C1/00 ; C07D401/12 ; C07D405/12 ; C07D413/12 ; C07D417/12 ; A61P11/00
摘要：
Compounds of general formula (I):
wherein R 1 , R 2 , R 3 , R 4 , R 5a , R 5b X 1 , X 2 , Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.
wherein R 1 , R 2 , R 3 , R 4 , R 5a , R 5b X 1 , X 2 , Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.
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