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公开(公告)号：EP3983389A1
公开(公告)日：2022-04-20
申请号：EP20734266.8
申请日：2020-06-12
申请人： TMEM16A LIMITED
发明人： COLLINGWOOD, Stephen , MCCARTHY, Clive , HAY, Duncan, Alexander , HARGRAVE, Jonathan, David , MA, Albert , SCHOFIELD, Thomas, Beauregard , SMITH, Matthew , WALKER, Edward , WENT, Naomi , INGRAM, Peter , STIMSON, Christopher , KHOR, Someina
IPC分类号： C07D231/56 , C07D235/08 , C07D235/12 , C07D235/14 , C07D263/56 , C07D405/06 , C07D413/10 , C07D471/04 , A61P11/12 , A61K31/437 , A61K31/416 , A61K31/4184 , A61K31/423
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2.发明公开
公开(公告)号：EP4003516A1
公开(公告)日：2022-06-01
申请号：EP20751234.4
申请日：2020-07-24
申请人： TMEM16A LIMITED
发明人： COLLINGWOOD, Stephen , BUXTON, Craig , HARGRAVE, Jonathan, David , INGRAM, Peter , SCHOFIELD, Thomas, Beauregard , SHAIKH, Abdul , STIMSON, Christopher
IPC分类号： A61P11/00 , A61K31/44 , C07D213/81 , C07D405/12
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公开(公告)号：EP4003977A1
公开(公告)日：2022-06-01
申请号：EP20751239.3
申请日：2020-07-24
申请人： TMEM16A LIMITED
发明人： COLLINGWOOD, Stephen , BUXTON, Craig , HABGOOD, Matthew , HARGRAVE, Jonathan, David , SCHOFIELD, Thomas, Beauregard , SMITH, Matthew , STIMSON, Christopher
IPC分类号： C07D401/12 , C07D401/14 , A61P11/00 , A61K31/44
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公开(公告)号：EP4215520A1
公开(公告)日：2023-07-26
申请号：EP22214010.5
申请日：2019-01-25
申请人： TMEM16A LIMITED
发明人： COLLINGWOOD, Stephen , MCCARTHY, Clive , HARGRAVE, Jonathan David , HAY, Duncan Alexander , SCHOFIELD, Thomas Beauregard , ELLAM, Sarah , BUXTON, Craig , HABGOOD, Matthew , INGRAM, Peter , MA, Chun Yan , SHAIKH, Abdul , SMITH, Matthew , STIMSON, Christopher , WALKER, Edward
IPC分类号： C07D213/72 , C07D309/10 , C07C1/00 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , A61P11/00
摘要： Compounds of general formula (I):
wherein R 1 , R 2 , R 3 , R 4 , R 5a , R 5b X 1 , X 2 , Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.
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