- 专利标题： COMPOSITIONS AND METHODS OF USE COMPRISING SUBSTANCES WITH NEURAL PLASTICITY ACTIONS ADMINISTERED AT NON-PSYCHEDELIC / PSYCHOTOMIMETIC DOSAGES AND FORMULATIONS
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申请号： EP23162430.5申请日： 2020-03-06
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公开(公告)号： EP4219498A1公开(公告)日： 2023-08-02
- 发明人: MANFREDI, Paolo L. , INTURRISI, Charles E. , DE MARTIN, Sara , MATTAREI, Andrea , ROLANDO, Maurizio , GIORDANO, Giovanni , LODOVICHI, Claudia , BRUN, Paola , PAPPAGALLO, Marco , FOLLI, Franco , ALIMONTI, Andrea , SGRIGNANI, Jacopo , CAVALLI, Andrea
- 申请人： Arbormentis LLC
- 申请人地址： US Miami Beach, FL 33139 5 Island Avenue 14J
- 代理机构： Mummery, Thomas Zack
- 优先权： US201962844151 P 20190507
- 主分类号： C07D471/18
- IPC分类号： C07D471/18 ; A61K31/137 ; A61K45/06
摘要：
Compositions and methods of use comprising serotonin (5-HT) receptor agonists of formula (II) and NMDAR modulating substances, including especially certain substances classified as 5-HT2A agonists presently disclosed to exert NMDAR modulating effects, administered as modulators of neural plasticity, at non-psychedelic / psychotomimetic dosages, posology and formulations, for treatment of diseases and conditions and for improving functions (neuroplastogens).
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