公开(公告)号：EP4377316A1

公开(公告)日：2024-06-05

申请号：EP22761074.8

申请日：2022-07-29

申请人： Guerbet

发明人： ROUSSEAUX, Olivier ,  PAULY - BATARD, William ,  FOUGERE, Olivier ,  CATOEN, Sarah

IPC分类号： C07D471/18 ,  C07D471/08 ,  A61P35/00 ,  A61K31/439

CPC分类号： C07D471/08 ,  C07D471/18 ,  A61P35/00

公开(公告)号：EP4196479B1

公开(公告)日：2023-11-01

申请号：EP22704452.6

申请日：2022-01-18

发明人： CHU, Hang ,  GONZALEZ BUENROSTRO, Ana Z. ,  GUO, Hongyan ,  HAN, Xiaochun ,  HURTLEY, Anna E. ,  JIANG, Lan ,  LI, Jiayao ,  LIN, David W. ,  MITCHELL, Michael L. ,  NADUTHAMBI, Devan ,  SCHWARZWALDER, Gregg M. ,  SZEWCZYK, Suzanne M. ,  VON BARGEN, Matthew J. ,  WU, Qiaoyin ,  YANG, Hong ,  ZHANG, Jennifer R.

IPC分类号： C07D471/18 ,  A61P31/18

公开(公告)号：EP4234634A3

公开(公告)日：2023-10-04

申请号：EP23168594.2

申请日：2020-05-12

申请人： Bracco Imaging SPA

发明人： BLASI, Francesco ,  BRIOSCHI, Chiara ,  BUONSANTI, Federica ,  MIRAGOLI, LUIGI ,  NAPOLITANO, Roberta ,  ORIO, Laura ,  PIZZUTO, Lorena ,  VALBUSA, Giovanni

IPC分类号： A61K49/00 ,  C07D471/18 ,  A61K39/00 ,  C07K7/52 ,  C07K16/28 ,  C07D209/14 ,  C07D403/12 ,  C07D417/14 ,  C09B23/08 ,  C09B23/06

摘要： The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

公开(公告)号：EP4219498A1

公开(公告)日：2023-08-02

申请号：EP23162430.5

申请日：2020-03-06

申请人： Arbormentis LLC

发明人： MANFREDI, Paolo L. ,  INTURRISI, Charles E. ,  DE MARTIN, Sara ,  MATTAREI, Andrea ,  ROLANDO, Maurizio ,  GIORDANO, Giovanni ,  LODOVICHI, Claudia ,  BRUN, Paola ,  PAPPAGALLO, Marco ,  FOLLI, Franco ,  ALIMONTI, Andrea ,  SGRIGNANI, Jacopo ,  CAVALLI, Andrea

IPC分类号： C07D471/18 ,  A61K31/137 ,  A61K45/06

摘要： Compositions and methods of use comprising serotonin (5-HT) receptor agonists of formula (II) and NMDAR modulating substances, including especially certain substances classified as 5-HT2A agonists presently disclosed to exert NMDAR modulating effects, administered as modulators of neural plasticity, at non-psychedelic / psychotomimetic dosages, posology and formulations, for treatment of diseases and conditions and for improving functions (neuroplastogens).

公开(公告)号：EP4151638A1

公开(公告)日：2023-03-22

申请号：EP21803295.1

申请日：2021-05-12

申请人： Neusco Biotech Limited

发明人： GU, Zhenghua ,  WANG, Dongqin

IPC分类号： C07D471/18 ,  C07D498/18 ,  A61K31/5386 ,  A61K31/529 ,  A61P25/28 ,  A61P27/06 ,  A61P27/02 ,  A61P9/10 ,  A61P3/10 ,  A61P13/08

摘要： Disclosed is an endocyclic pyrimidinone compound of Formula (I) or a pharmaceutically acceptable salt thereof, which is an entirely new Lp-PLA2 inhibitor useful in treating neurodegeneration-related diseases such as Alzheimer's disease (AD), glaucoma and age-related macular degeneration (AMD), or cardiovascular diseases including atherosclerosis.

公开(公告)号：EP4062972A1

公开(公告)日：2022-09-28

申请号：EP20890718.8

申请日：2020-11-20

申请人： The Kitasato Institute ,  Nippon Chemiphar Co., Ltd.

发明人： FUJII, Hideaki ,  HIRAYAMA, Shigeto ,  WATANABE, Yoshikazu

IPC分类号： A61P13/02 ,  A61P25/04 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D471/18 ,  A61K31/439

摘要： The present invention provides a compound having a selective opioid δ receptor agonist effect. The present invention provides a pyrazolomorphinan derivative represented by general formula (1) (in the formula, (II) R 1 represents a hydrogen atom, an alkyl group, a cycloalkylmethyl group, or the like, R 2 represents a hydrogen atom or a hydroxy protecting group, R 3 represents a hydroxy group, an alkyl group, a partially unsaturated heterocyclic group, an aryl group, a heteroaryl group, or the like; and R 4 represents a hydrogen atom, an alkyl group, an aralkyl group, a cycloalkyl group, a cycloalkyl alkyl group, a saturated heterocyclic group, an aryl group, a heteroaryl group, or the like). The pyrazolomorphinan derivative can be used as an active ingredient in an analgesic, an antidepressant, an anxiolytic, or the like.

公开(公告)号：EP3589287B1

公开(公告)日：2022-09-14

申请号：EP18760627.2

申请日：2018-03-01

发明人： WILES, Jason, Allan ,  PHADKE, Avinash, S. ,  CHEN, Dawei ,  GADHACHANDA, Venkat, Rao ,  BARRISH, Joel, Charles ,  AGARWAL, Atul ,  EASTMAN, Kyle, J.

IPC分类号： C07D498/08 ,  C07D487/18 ,  C07D471/18 ,  A61K31/53 ,  A61P31/12

公开(公告)号：EP3608325B1

公开(公告)日：2022-07-06

申请号：EP19185121.1

申请日：2013-12-19

发明人： HAOLUN, Jin ,  LAZERWITH, Scott, E. ,  MARTIN, Teresa, Alejandra, Trejo ,  BACON, Elizabeth, M. ,  COTTELL, Jeromy, J. ,  CAI, Zhenhong, R. ,  PYUN, Hyung-Jung ,  MORGANELLI, Phillip, Anthony ,  JI, Mingzhe ,  TAYLOR, James, G. ,  CHEN, Xiaowu ,  MISH, Michael, R. ,  DESAI, Manoj, C.

IPC分类号： A61P31/12 ,  A61P31/18 ,  A61P43/00 ,  C07D471/22 ,  A61K31/4985 ,  C07D498/18 ,  C07D487/14 ,  C07D471/18 ,  A61K45/06 ,  A61K31/553 ,  A61K31/529

公开(公告)号：EP3957638A1

公开(公告)日：2022-02-23

申请号：EP20792125.5

申请日：2020-04-15

申请人： Medshine Discovery Inc.

发明人： CAI, Yaxian ,  YAN, Xiaobing ,  WANG, Ting ,  WU, Chengde ,  DING, Charles Z. ,  CHEN, Shuhui

IPC分类号： C07D471/18 ,  C07D487/18 ,  A61K31/439 ,  A61K31/366 ,  A61P9/10

摘要： Disclosed are a class of macrocyclic derivatives, a preparation method therefor, a pharmaceutical composition containing the derivatives, and the use thereof as therapeutic agents, particularly as XIa factor inhibitors and in the preparation of a drug for treating and preventing thromboembolisms and other diseases. Particularly disclosed are compounds shown by formula (I), an isomer thereof and a pharmaceutically acceptable salt thereof.

公开(公告)号：EP3953334A1

公开(公告)日：2022-02-16

申请号：EP20721374.5

申请日：2020-04-10

申请人： Bristol-Myers Squibb Company ,  Janssen Pharmaceutica NV

发明人： CUNIERE, Nicolas ,  FAN, Yu ,  KOLOTUCHIN, Sergei ,  MUKHERJEE, Subha ,  SIMMONS, Eric M. ,  SINGH, Amarjit ,  WEI, Carolyn S. ,  XIAO, Yi ,  YUAN, Changxia ,  ZHENG, Bin ,  WAGSCHAL, Simon Albert ,  BROGGINI, Diego Fernando Domenico ,  CAO, Duy Chi Trung ,  CHERNICHENKO, Kostiantyn ,  LEMAIRE, Sébastien François Emmanuel ,  BEN HAIM, Cyril

IPC分类号： C07D213/61 ,  C07D401/04 ,  C07D471/18