- 专利标题： METHODS FOR IMPROVING THE EFFICACY AND EXPANSION OF CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS
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申请号： EP23159683.4申请日： 2016-04-15
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公开(公告)号： EP4234685A3公开(公告)日： 2023-09-06
- 发明人: BARRETT, David, Maxwell , BEDOYA, Filipe , GHASSEMI, Saba , JUNE, Carl, H. , LEVINE, Bruce, L. , MELENHORST, Jan, J. , MILONE, Michael, C. , POWELL, Daniel, J. , SINGH, Nathan, Amar , ZHENG, Zoe
- 申请人： Novartis AG , The Trustees of The University of Pennsylvania
- 申请人地址： CH 4056 Basel Lichtstrasse 35; US Philadelphia, PA 19104 3600 Civic Center Boulevard, 9th Floor
- 代理机构： Mathys & Squire
- 优先权： US201562149249 P 20150417
- 主分类号： C12N5/0783
- IPC分类号： C12N5/0783 ; C07K14/47 ; C07K14/705 ; C12N5/00 ; A61K35/17
摘要：
The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.
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