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    HIGH DENSITY ELECTRODE MAPPING CATHETER
    5.
    发明公开
    HIGH DENSITY ELECTRODE MAPPING CATHETER 审中-公开

    公开(公告)号：EP4417112A3

    公开(公告)日：2024-11-13

    申请号：EP24186941.1

    申请日：2016-10-21

    申请人： St. Jude Medical, Cardiology Division, Inc.

    发明人： DE LA RAMA, Alan ,  HATA, Cary ,  LA, Tim

    IPC分类号： A61B18/14 ,  A61B5/287 ,  A61B5/00

    摘要： Various embodiments of the present disclosure can include a flexible catheter tip. The flexible catheter tip can comprise an inboard understructure that defines a tip longitudinal axis, wherein the inboard understructure is formed from a first continuous element that includes a first rectangular cross-section. In some embodiments, an outboard understructure can extend along the tip longitudinal axis, wherein the outboard understructure is formed from a second continuous element that includes a second rectangular cross-section.

    OPTIMIZED LENTIVIRAL TRANSFER VECTORS AND USES THEREOF
    7.
    发明公开
    OPTIMIZED LENTIVIRAL TRANSFER VECTORS AND USES THEREOF 审中-公开

    公开(公告)号：EP4458957A2

    公开(公告)日：2024-11-06

    申请号：EP24185321.7

    申请日：2016-11-23

    申请人： Novartis AG ,  The Trustees of The University of Pennsylvania

    发明人： SLEPUSHKIN, Vladimir ,  LUKASHEV, Dmitriy

    IPC分类号： C12N5/10

    摘要： The invention features lentiviral transfer vectors that include heterologous nucleic acids to be introduced into a cell. The lentiviral transfer vector may be characterized by the following features: (a) including a cytomegalovirus (CMV) promoter; (b) including a polynucleotide encoding a partial gag protein that includes a mutated INS1 inhibitory sequence that reduces restriction of nuclear export of RNA; (c) not including a polynucleotide encoding the INS2, INS3, and INS4 inhibitory sequences of gag; (d) not including an SV40 origin of replication and/or an f1 origin of replication; (e) including a cPPT sequence that contains splice site; (f) including an EF1 alpha promoter with intact splice donor and acceptor sites; and (g) including hepatitis B PRE with mutation in start codon of X protein ORF.