- 专利标题： HYDROGEL FOR IN-VIVO RELEASE OF MEDICATION
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申请号： EP23177683.2申请日： 2020-06-11
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公开(公告)号： EP4238582A2公开(公告)日： 2023-09-06
- 发明人: PILUSO, Susanna , STEVERINK, Jasper Gerard , VERLAAN, Joannes Jacobus , OOSTERMAN, Bas Jeroen
- 申请人： UMC Utrecht Holding B.V. , Sentryx B.V. , BO-IP B.V.
- 申请人地址： NL 3584 CS Utrecht Heidelberglaan 8; NL 3711 AA Austerlitz Woudenbergseweg 41; NL 3708 ZV Zeist Prinses Maximalaan 18
- 代理机构： EP&C
- 优先权： WOPCT/NL2019/050352 20190611
- 主分类号： A61K47/69
- IPC分类号： A61K47/69 ; A61K47/61 ; A61K31/445 ; A61L27/00 ; A61P19/00 ; A61P23/02 ; A61K45/06 ; A61K9/00 ; A61K9/127
摘要：
The present invention relates to a hydrogel for in-vivo release of medication comprising at least one medication, wherein the hydrogel comprises
(i) a protein-based biopolymer functionalized with a functionalisation agent that is able to form guest-host interactions with oxidized β-cyclodextrin, preferably a primary aminoalkylphenol, more preferably gelatin functionalized with tyramine (GTA) and
(ii) oxidized β-cyclodextrin (oβ-CD),
wherein the hydrogel is cross-linked via exposure to visible light in presence of a biocompatible photoinitiator, resulting in a degree of swelling in the range of 2-20 calculated as (swollen weight - dry weight)/dry weight. It further relates to a method for its preparation, as well as to a medication for treatment of musculoskeletal disorders, preferably for treatment of infection, inflammation, malignant processes, growth disorders, degenerative disorders or treatment of pain arising from (surgical treatment of) these disorders.
(i) a protein-based biopolymer functionalized with a functionalisation agent that is able to form guest-host interactions with oxidized β-cyclodextrin, preferably a primary aminoalkylphenol, more preferably gelatin functionalized with tyramine (GTA) and
(ii) oxidized β-cyclodextrin (oβ-CD),
wherein the hydrogel is cross-linked via exposure to visible light in presence of a biocompatible photoinitiator, resulting in a degree of swelling in the range of 2-20 calculated as (swollen weight - dry weight)/dry weight. It further relates to a method for its preparation, as well as to a medication for treatment of musculoskeletal disorders, preferably for treatment of infection, inflammation, malignant processes, growth disorders, degenerative disorders or treatment of pain arising from (surgical treatment of) these disorders.
公开/授权文献
- EP4238582A3 HYDROGEL FOR IN-VIVO RELEASE OF MEDICATION 公开/授权日：2023-10-25
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