公开(公告)号：EP4396211A2

公开(公告)日：2024-07-10

申请号：EP22772477.0

申请日：2022-08-30

申请人： UMC Utrecht Holding B.V.

发明人： PEPERZAK, Victor ,  SEBESTYEN, Zsolt ,  KIMMAN, Thomas

IPC分类号： C07K14/47 ,  A61K35/17

CPC分类号： C07K14/4747 ,  C12N9/6467 ,  C07K2319/05520130101 ,  C12Y304/21079 ,  A61K38/00

公开(公告)号：EP4238582A2

公开(公告)日：2023-09-06

申请号：EP23177683.2

申请日：2020-06-11

申请人： UMC Utrecht Holding B.V. ,  Sentryx B.V. ,  BO-IP B.V.

发明人： PILUSO, Susanna ,  STEVERINK, Jasper Gerard ,  VERLAAN, Joannes Jacobus ,  OOSTERMAN, Bas Jeroen

IPC分类号： A61K47/69 ,  A61K47/61 ,  A61K31/445 ,  A61L27/00 ,  A61P19/00 ,  A61P23/02 ,  A61K45/06 ,  A61K9/00 ,  A61K9/127

摘要： The present invention relates to a hydrogel for in-vivo release of medication comprising at least one medication, wherein the hydrogel comprises
(i) a protein-based biopolymer functionalized with a functionalisation agent that is able to form guest-host interactions with oxidized β-cyclodextrin, preferably a primary aminoalkylphenol, more preferably gelatin functionalized with tyramine (GTA) and
(ii) oxidized β-cyclodextrin (oβ-CD),
wherein the hydrogel is cross-linked via exposure to visible light in presence of a biocompatible photoinitiator, resulting in a degree of swelling in the range of 2-20 calculated as (swollen weight - dry weight)/dry weight. It further relates to a method for its preparation, as well as to a medication for treatment of musculoskeletal disorders, preferably for treatment of infection, inflammation, malignant processes, growth disorders, degenerative disorders or treatment of pain arising from (surgical treatment of) these disorders.

公开(公告)号：EP4233747A2

公开(公告)日：2023-08-30

申请号：EP23177302.9

申请日：2018-12-12

申请人： BO-IP B.V. ,  UMC Utrecht Holding B.V.

发明人： VERLAAN, Joannes Jacobus ,  OOSTERMAN, Bas Jeroen

IPC分类号： A61B17/56

摘要： The present invention provides a deformable body,
wherein the deformable body comprises a bone contact surface to be pressed against periosteum of a bone surface of a bone such that the bone contact surface adapts its shape to the shape of the bone surface,
wherein the deformable body comprises one or more through-going openings and/or one or more fixation locations arranged to receive a fixation element, and wherein the deformable body comprises an anaesthetic that is released from or through the bone contact surface.

公开(公告)号：EP4164642A1

公开(公告)日：2023-04-19

申请号：EP21730627.3

申请日：2021-06-10

申请人： UMC Utrecht Holding B.V. ,  Sentryx B.V.

发明人： PILUSO, Susanna ,  STEVERINK, Jasper, Gerard ,  VAN TOL, Floris, Rudolf ,  SCHIFFELERS, Raymond, Michel ,  OOSTERMAN, Bas, Jeroen ,  VERLAAN, Joannes, Jacobus

IPC分类号： A61K31/445 ,  A61K47/61 ,  A61K47/69 ,  A61K47/40 ,  A61K47/42 ,  A61K9/00 ,  A61L24/00

公开(公告)号：EP4056152A1

公开(公告)日：2022-09-14

申请号：EP21208100.4

申请日：2021-11-12

申请人： Common Sense Engineering and Consult B.V. ,  UMC Utrecht Holding B.V.

发明人： WEINANS, Hermannus Hendricus ,  MERCELIS, Peter

IPC分类号： A61F2/30 ,  A61F2/32 ,  A61F2/34

摘要： Acetabular implant and method for its manufacture, wherein the implant (3) has a bone side (4) with a contact surface (5) to be fixed against the bone of the hip socket (2). A plastically deformable zone (12) with an open porous structure connects to the contact surface (5), said zone (12) being formed by a three-dimensional structure composed of strut elements (15) with opposite ends, wherein these strut elements (15) are connected at their ends in nodes (14). The zone (12) is made of a material having an elongation at break of at least 15%.

公开(公告)号：EP4050359A1

公开(公告)日：2022-08-31

申请号：EP21174038.6

申请日：2021-05-17

申请人： Tesla Dynamic Coils BV ,  UMC Utrecht Holding B.V. ,  Futura Composites B.V.

发明人： VAN LEEUWEN, Carel Costijn ,  RAAIJMAKERS, Alexander Jan Eberhard ,  STEENSMA, Bart Romke ,  BORGO, Martino ,  ARTEAGA DE CASTRO, Catalina Sofia ,  VAN DEN BERG, Cornelis Antonius ,  KLOMP, Dennis Wilhelmus Johannes

IPC分类号： G01R33/34 ,  G01R33/341 ,  G01R33/343 ,  G01R33/345 ,  H01Q9/22

摘要： An MRI system RF transmit antenna arrangement 3 comprising an antenna 5 comprising a length of coaxial cable 51 with an electrically conductive core 52 and an electrically conductive outer shield 53 through which the core runs, with the core having a feed point 52a arranged for electrical connection to an RF source and at least one break 53a being provided in the electrically conductive outer shield partway along the length of coaxial cable so as to divide the electrically conductive outer shield 53 into at least two axially spaced shield portions such that at least one of the shield portions acts as a radiating element when an RF source is connected to the feed point 52a.

公开(公告)号：EP3801748A1

公开(公告)日：2021-04-14

申请号：EP19731566.6

申请日：2019-06-03

申请人： Medtronic, Inc. ,  UMC Utrecht Holding B.V.

发明人： ARANDA HERNANDEZ, Alfonso ,  STEGEMANN, Berthold ,  VOS, Marc, A. ,  SPRENKELER, David, J.

IPC分类号： A61N1/365 ,  A61B5/0452

公开(公告)号：EP3684818A2

公开(公告)日：2020-07-29

申请号：EP18812321.0

申请日：2018-09-21

申请人： UMC Utrecht Holding B.V.

发明人： LEUSEN, Jeanette Henrica Wilhelmina ,  EVERS, Johannes Gerardus Maria

IPC分类号： C07K16/30 ,  A61K39/00

公开(公告)号：EP3328298A1

公开(公告)日：2018-06-06

申请号：EP15750960.5

申请日：2015-07-30

申请人： UMC Utrecht Holding B.V.

发明人： STRUIK, Thijmen ,  LAFEBER, Floris Paulus Jacobus Gerardus ,  LINDENHOVIUS, Karianne Hilde ,  VAN ROERMUND, Petrus Maria ,  CLOOSTERMANS, Vincent Marianus ,  MASTBERGEN, Simon Carl

IPC分类号： A61B17/17 ,  A61B17/64 ,  A61B17/66

CPC分类号： A61B17/171 ,  A61B17/6466 ,  A61B17/66 ,  A61B2017/90

摘要： System for connecting a connection device to a bone with a bone pin, wherein the connection device is provided with an opening for receiving the bone pin, wherein the system comprises: —said connection device; —a guiding tube arranged to guide the bone pin from the connection device to the bone for connecting the bone pin to the bone, wherein the inner diameter of the guiding tube corresponds to the outer diameter of the bone pin and wherein the guiding tube can be slidably received in the opening, the guiding tube being slidable with respect to the connection device along an axis parallel to a longitudinal axis of the opening; —a locking device arranged to be received in the opening of the connection device and arranged to engage the bone pin for locking the bone pin with respect to the connection device, wherein the guiding tube is movable with respect to the connection device and bone pin such that the guiding tube is removable from the combination of the bone pin and the connection device and wherein the locking device is arranged to lock the bone pin after removal of the guiding tube.

公开(公告)号：EP3258987A1

公开(公告)日：2017-12-27

申请号：EP15718762.6

申请日：2015-02-19

申请人： UMC Utrecht Holding B.V.

发明人： RIPHAGEN, Brechtje ,  EVERS, Lucas Alphonsus Maria ,  MIJERS, Jan Willem Marinus ,  VAN ROSSUM, Lex Alexander Franciscus

IPC分类号： A61M5/14 ,  A61M5/168 ,  A61M39/24 ,  A61M5/165 ,  A61M39/22

CPC分类号： A61M5/165 ,  A61L31/048 ,  A61L31/14 ,  A61M5/1408 ,  A61M5/1412 ,  A61M5/16827 ,  A61M5/385 ,  A61M39/223 ,  A61M39/24 ,  A61M2005/1652 ,  A61M2205/0216 ,  A61M2205/3306 ,  A61M2205/584 ,  A61M2205/75

摘要： A device 2 for the administration of fluids to a human or animal body comprising a housing 3 with a first inlet 28, at least one second inlet 29, 30, one outlet 31 and a collecting point, wherein the first inlet 28 communicates with the collecting point through a first channel and the outlet 31 communicates with the collecting point. The second inlet 29, 30 communicates with the collecting point or an indicator chamber 24, 25 through a second channel 21, 22 in which a valve 26, 27 is arranged, the valve 26, 27 being adjustable between a first position and a second position, wherein, in the first position of the valve 26, 27, the second channel 26, 27 communicates with the indicator chamber 24, 25 and, in the second position of the valve 26, 27, the second channel 21, 22 communicates with the collecting point.