- 专利标题： HUMANIZED SIRPA-IL15 KNOCKIN MICE AND METHODS OF USE THEREOF
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申请号： EP23175415.1申请日： 2016-04-12
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公开(公告)号： EP4248740A2公开(公告)日： 2023-09-27
- 发明人: HERNDLER-BRANDSTETTER, Dietmar , FLAVELL, Richard A. , FRLETA, Davor , GURER, Cagan , MANZ, Markus, Gabriel , MURPHY, Andrew, J. , PALM, Noah, W. , SHAN, Liang , STEVENS, Sean , STROWIG, Till , YANCOPOULOS, George, D. , DE ZOETE, Marcel
- 申请人： Regeneron Pharmaceuticals, Inc. , Yale University , Institute for Research in Biomedicine (IRB)
- 申请人地址： US Tarrytown, NY 10591-6707 777 Old Saw Mill River Road; US New Haven CT 06510 Two Whitney Avenue; CH 6500 Bellinzona Via Francesco Chiesa 5
- 代理机构： Mewburn Ellis LLP
- 优先权： US201662287842 P 20160127
- 主分类号： A01K39/00
- IPC分类号： A01K39/00
摘要：
Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.
公开/授权文献
- EP4248740A3 HUMANIZED SIRPA-IL15 KNOCKIN MICE AND METHODS OF USE THEREOF 公开/授权日：2023-12-27
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