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公开(公告)号：EP4248740A3
公开(公告)日：2023-12-27
申请号：EP23175415.1
申请日：2016-04-12
申请人： Regeneron Pharmaceuticals, Inc. , Yale University , Institute for Research in Biomedicine (IRB)
发明人： HERNDLER-BRANDSTETTER, Dietmar , FLAVELL, Richard A. , FRLETA, Davor , GURER, Cagan , MANZ, Markus, Gabriel , MURPHY, Andrew, J. , PALM, Noah, W. , SHAN, Liang , STEVENS, Sean , STROWIG, Till , YANCOPOULOS, George, D. , DE ZOETE, Marcel
IPC分类号： A01K67/027 , A01K39/00 , A61P35/00 , C07K14/47 , C07K14/54
摘要： Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.
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公开(公告)号：EP4248740A2
公开(公告)日：2023-09-27
申请号：EP23175415.1
申请日：2016-04-12
申请人： Regeneron Pharmaceuticals, Inc. , Yale University , Institute for Research in Biomedicine (IRB)
发明人： HERNDLER-BRANDSTETTER, Dietmar , FLAVELL, Richard A. , FRLETA, Davor , GURER, Cagan , MANZ, Markus, Gabriel , MURPHY, Andrew, J. , PALM, Noah, W. , SHAN, Liang , STEVENS, Sean , STROWIG, Till , YANCOPOULOS, George, D. , DE ZOETE, Marcel
IPC分类号： A01K39/00
摘要： Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.
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公开(公告)号：EP4193834A1
公开(公告)日：2023-06-14
申请号：EP22208636.5
申请日：2013-09-06
申请人： Yale University , Institute for Research in Biomedicine (IRB) , Regeneron Pharmaceuticals, Inc.
发明人： FLAVELL, Richard, A/ , MANZ, Markus , RONGVAUX, Anthony , STROWIG, Till , WILLINGER, Tim , YANCOPOULOS, George , STEVENS, Sean , MURPHY, Andrew, J.
IPC分类号： A01K67/027 , A01K39/00
摘要： The invention relates generally to genetically modified non-human animals expressing human polypeptides and their methods of use.
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公开(公告)号：EP2892330A2
公开(公告)日：2015-07-15
申请号：EP13834735.6
申请日：2013-09-06
申请人： Yale University , Institute for Research in Biomedicine (IRB) , Regeneron Pharmaceuticals, Inc.
发明人： FLAVELL, Richard, A. , MANZ, Markus , RONGVAUX, Anthony , STROWIG, Till , WILLINGER, Tim , YANCOPOULOS, George , STEVENS, Sean , MURPHY, Andrew, J.
IPC分类号： A01K67/027
CPC分类号： A01K67/0278 , A01K67/0271 , A01K2207/12 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/0331 , A01K2267/0381 , A01K2267/0387 , C12N15/87
摘要： The invention relates generally to genetically modified non-human animals expressing human polypeptides and their methods of use.
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公开(公告)号：EP4248744A2
公开(公告)日：2023-09-27
申请号：EP23175865.7
申请日：2016-04-06
IPC分类号： A01K67/027
摘要： Disclosed herein are non-human animals (e.g., rodents, e.g., mice or rats) genetically engineered to express a humanized T cell co-receptor (e.g., humanized CD4 and/or CD8 (e.g., CD8α and/or CD8β)), a human or humanized T cell receptor (TCR) comprising a variable domain encoded by at least one human TCR variable region gene segment and/or a human or humanized major histocompatibility complex that binds the humanized T cell co-receptor (e.g., human or humanized MHC II (e.g., MHC II α and/or MHC II β chains) and/or MHC I (e.g., MHC Iα) respectively, and optionally human or humanized β2 microglobulin) . Also provided are embryos, tissues, and cells expressing the same. Methods for making a genetically engineered animal that expresses at least one humanized T cell co-receptor (e.g., humanized CD4 and/or CD8), at least one humanized MHC that associates with the humanized T cell co-receptor (e.g., humanized MHC II and/or MHC I, respectively) and/or the humanized TCR are also provided. Methods for using the genetically engineered animals that mount a substantially humanized T cell immune response for developing human therapeutics are also provided.
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公开(公告)号：EP2834272B1
公开(公告)日：2020-06-24
申请号：EP13716138.6
申请日：2013-04-02
发明人： MURPHY, Andrew, J. , KOSTIC, Ana
IPC分类号： C07K16/28
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公开(公告)号：EP3407709A1
公开(公告)日：2018-12-05
申请号：EP17863293.1
申请日：2017-11-03
发明人： GUO, Chunguang , HARRIS, Faith , VORONINA, Vera , MCWHIRTER, John , LEVENKONA, Natasha , MACDONALD, Lynn , TU, Naxin , MURPHY, Andrew, J.
IPC分类号： A01K67/027 , C12N15/90 , C12N15/85 , C07K16/00
摘要： Non-human animals (and/or non-human cells) and methods of using and making the same are provided, which non-human animals (and/or non-human cells) have a genome comprising human antibody-encoding sequences (i.e., immunoglobulin genes). Non-human animals described herein express antibodies that contain human Igλ light chains, in whole or in part. In particular, non-human animals provided herein are, in some embodiments, characterized by expression of antibodies that contain human Igλ light chains, in whole or in part, that are encoded by human Igλ light chain-encoding sequences inserted into an endogenous Igλ light chain locus of said non-human animals. Methods for producing antibodies from non-human animals are also provided.
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公开(公告)号：EP3336102A2
公开(公告)日：2018-06-20
申请号：EP18154933.8
申请日：2010-12-17
发明人： MACDONALD, Lynn , TU, Naxin , GURER, Cagan , STEVENS, Sean , MURPHY, Andrew, J.
IPC分类号： C07K14/705 , A01K67/027
CPC分类号： A61K49/0008 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/03 , A01K2267/0387 , C07K14/70535 , G01N33/5014
摘要： Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided.
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公开(公告)号：EP3193592A1
公开(公告)日：2017-07-26
申请号：EP15775854.1
申请日：2015-09-18
发明人： THURSTON, Gavin , MURPHY, Andrew, J. , MACDONALD, Lynn , MCWHIRTER, John , TU, Naxin , GURER, Cagan , VORONINA, Vera
IPC分类号： A01K67/027 , C07K14/725 , C07K19/00 , C07K16/00
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K14/7051 , C07K16/00 , C07K16/2833 , C07K16/3069 , C07K2319/00 , C07K2319/33 , C07K2319/50 , C12N15/907
摘要： Provided herein are methods and compositions related to chimeric antigen receptors (CARs) having antigen binding domains derived from an immunoglobulin (Ig) and constant domains derived from a T cell receptor (TCR).
摘要翻译： 本文提供了涉及具有源自免疫球蛋白（Ig）的抗原结合结构域和源自T细胞受体（TCR）的恒定结构域的嵌合抗原受体（CAR）的方法和组合物。
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公开(公告)号：EP2701499B9
公开(公告)日：2016-05-18
申请号：EP12717033.0
申请日：2012-04-24
发明人： MCWHIRTER, John , MACDONALD, Lynn , STEVENS, Sean , DAVIS, Samuel , BUCKLER, David, R. , HOSIAWA, Karolina, A. , MURPHY, Andrew, J.
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/76 , C07K2319/30 , C12N15/8509 , C12N2800/204
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