- 专利标题: METHOD FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS THROUGH CO-ADMINISTRATION OF CURCUMIN DERIVATIVE AND TGF-? RECEPTOR INHIBITOR
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申请号: EP22828609.2申请日: 2022-05-13
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公开(公告)号: EP4248957A1公开(公告)日: 2023-09-27
- 发明人: CHUNG, Choon Hee , LEE, Eun Soo , HA, Kyung Bong , LEE, Dong Keon , PARK, Na Won , JO, Su Ho
- 申请人: University Industry Foundation, Yonsei University Wonju Campus
- 申请人地址: KR Gangwon-do 26493 1 Yeonsedae-gil Heungeop-myeon Wonju-si
- 代理机构: Vossius & Partner Patentanwälte Rechtsanwälte mbB
- 优先权: KR20210160931 20211122
- 国际公布: WO2022270760 20221229
- 主分类号: A61K31/12
- IPC分类号: A61K31/12 ; A61K31/444 ; A61K45/06 ; A61P1/16 ; A23L33/10
摘要:
The present invention relates to a pharmaceutical composition, quasi-drug, and food composition for preventing, ameliorating, or treating steatohepatitis, comprising a curcumin derivative and a TGF-β receptor inhibitor as active ingredients. In the composition, the TGF-β receptor inhibitor inhibits fibrosis of liver tissues, the curcumin derivative inhibits adipogenesis of hepatocyte increased during fibrosis inhibition process. Thus, compared to when a curcumin derivative or a TGF-β receptor inhibitor is administered alone as in the conventional cases, the composition exhibits an excellent effect of preventing and treating steatohepatitis, and therefore, can be used as a pharmaceutical composition, quasi-drug, and food composition for preventing, ameliorating, or treating metabolic liver diseases, including steatohepatitis.
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