公开(公告)号：EP4248957A1

公开(公告)日：2023-09-27

申请号：EP22828609.2

申请日：2022-05-13

申请人： University Industry Foundation, Yonsei University Wonju Campus

发明人： CHUNG, Choon Hee ,  LEE, Eun Soo ,  HA, Kyung Bong ,  LEE, Dong Keon ,  PARK, Na Won ,  JO, Su Ho

IPC分类号： A61K31/12 ,  A61K31/444 ,  A61K45/06 ,  A61P1/16 ,  A23L33/10

摘要： The present invention relates to a pharmaceutical composition, quasi-drug, and food composition for preventing, ameliorating, or treating steatohepatitis, comprising a curcumin derivative and a TGF-β receptor inhibitor as active ingredients. In the composition, the TGF-β receptor inhibitor inhibits fibrosis of liver tissues, the curcumin derivative inhibits adipogenesis of hepatocyte increased during fibrosis inhibition process. Thus, compared to when a curcumin derivative or a TGF-β receptor inhibitor is administered alone as in the conventional cases, the composition exhibits an excellent effect of preventing and treating steatohepatitis, and therefore, can be used as a pharmaceutical composition, quasi-drug, and food composition for preventing, ameliorating, or treating metabolic liver diseases, including steatohepatitis.

公开(公告)号：EP4248957A8

公开(公告)日：2023-11-29

申请号：EP22828609.2

申请日：2022-05-13

申请人： University Industry Foundation, Yonsei University Wonju Campus

发明人： CHUNG, Choon Hee ,  LEE, Eun Soo ,  HA, Kyung Bong ,  LEE, Dong Keon ,  PARK, Na Won ,  JO, Su Ho

IPC分类号： A61K31/12 ,  A61K31/444 ,  A61K45/06 ,  A61P1/16 ,  A23L33/10

摘要： The present invention relates to a pharmaceutical composition, quasi-drug, and food composition for preventing, ameliorating, or treating steatohepatitis, comprising a curcumin derivative and a TGF-β receptor inhibitor as active ingredients. In the composition, the TGF-β receptor inhibitor inhibits fibrosis of liver tissues, the curcumin derivative inhibits adipogenesis of hepatocyte increased during fibrosis inhibition process. Thus, compared to when a curcumin derivative or a TGF-β receptor inhibitor is administered alone as in the conventional cases, the composition exhibits an excellent effect of preventing and treating steatohepatitis, and therefore, can be used as a pharmaceutical composition, quasi-drug, and food composition for preventing, ameliorating, or treating metabolic liver diseases, including steatohepatitis.