- 专利标题： SMALL MOLECULE INHIBITOR OF CATHEPSIN C AND MEDICINAL USE THEREOF
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申请号： EP21900085.8申请日： 2021-12-03
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公开(公告)号： EP4257588A1公开(公告)日： 2023-10-11
- 发明人: HAO, Xin , GONG, Shuyi , SHEN, Defeng , DU, Xinming
- 申请人： Reistone Biopharma Company Limited
- 申请人地址： CN Shanghai 201210 Room 203, No.1 Building, No.298 Xiangke Road Free Trade Pilot Zone, Pudong New Area
- 代理机构： EP&C
- 优先权： CN202110910610 20210809
- 国际公布： WO2022117059 20220609
- 主分类号： C07D471/14
- IPC分类号： C07D471/14 ; C07D493/14 ; C07C13/60 ; A61K31/4353 ; A61K31/438 ; A61K31/352 ; A61P11/06 ; A61P11/08 ; A61P19/02 ; A61P3/10 ; A61P37/00 ; A61P13/12
摘要：
The present disclosure relates to a small molecule inhibitor of cathepsin C and the medicinal use thereof. Specifically, provided in the present disclosure are an amide nitrile compound represented by formula VI, a pharmaceutical composition containing the compound, and the use thereof in the inhibition of cathepsin C.
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