公开(公告)号：EP4257588A1

公开(公告)日：2023-10-11

申请号：EP21900085.8

申请日：2021-12-03

申请人： Reistone Biopharma Company Limited

发明人： HAO, Xin ,  GONG, Shuyi ,  SHEN, Defeng ,  DU, Xinming

IPC分类号： C07D471/14 ,  C07D493/14 ,  C07C13/60 ,  A61K31/4353 ,  A61K31/438 ,  A61K31/352 ,  A61P11/06 ,  A61P11/08 ,  A61P19/02 ,  A61P3/10 ,  A61P37/00 ,  A61P13/12

摘要： The present disclosure relates to a small molecule inhibitor of cathepsin C and the medicinal use thereof. Specifically, provided in the present disclosure are an amide nitrile compound represented by formula VI, a pharmaceutical composition containing the compound, and the use thereof in the inhibition of cathepsin C.