- 专利标题： CYTOCHROME P450 ENZYME MUTANT AND APPLICATION THEREOF
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申请号： EP21918810.9申请日： 2021-04-25
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公开(公告)号： EP4257679A1公开(公告)日： 2023-10-11
- 发明人: HONG, Hao , JAMES, Gage , ZHANG, Na , JIAO, Xuecheng , MA, Yulei , CAO, Shan , CHENG, Yibing , SUN, Kaihua
- 申请人： Asymchem Life Science (Tianjin) Co., Ltd.
- 申请人地址： CN Tianjin 300457 No. 71, 7th Avenue TEDA
- 代理机构： Delbarba, Andrea
- 优先权： CN202110039458 20210113
- 国际公布： WO2022151611 20220721
- 主分类号： C12N9/02
- IPC分类号： C12N9/02 ; C12N15/53 ; C12N15/70 ; C12N1/21 ; C12P7/24 ; C12P7/02 ; C12R1/19
摘要：
Provided are a cytochrome P450 enzyme mutant and an application thereof. The enzyme activity and anti-Markov oxidation selectivity of P450 derived from a wild-type strain of Bacillus megaterium undergo protein modification by means of directed evolution, thus improving enzyme activity and selectivity, and developing a series of P450 enzyme mutants that may be used for industrial production.
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