公开(公告)号：EP4512891A1

公开(公告)日：2025-02-26

申请号：EP22938043.1

申请日：2022-05-17

Applicant: Asymchem Laboratories (Tianjin) Co., Ltd.

Inventor： HONG, Hao ,  JAMES, Gage ,  XIAO, Yi ,  ZHANG, Na ,  JIAO, Xuecheng ,  ZHANG, Kejian ,  WANG, Lei ,  ZHAO, Junqi ,  LING, Jun ,  XU, Xinsheng ,  LI, Rui ,  WANG, Zujian

IPC: C12N9/10 ,  C12N15/54 ,  C12N15/70 ,  C12N15/81 ,  C12N1/19 ,  C12N1/21 ,  C12P13/00 ,  C12R1/19 ,  C12R1/645

Abstract: Provided are a transaminase mutant and use thereof. The transaminase mutant is obtained by mutation occurred in an amino acid sequence as shown in SEQ ID NO:1, and the mutation includes at least T291A; or an amino acid sequence of the transaminase mutant has the mutation in the mutated amino acid sequence, and has more than 80% of identity with the mutated amino acid sequence, preferably has 85% of identity, and more preferably has 90% of identity. The transaminase mutant expands a substrate spectrum of enzymes, improves stereoselectivity, and improves the catalytic capacity of a large steric hindrance substrate; and at the same time, the stability of the enzymes is improved, and a catalytic reaction may be performed to produce chiral amines at high solvent concentrations and high temperatures.

公开(公告)号：EP4512825A1

公开(公告)日：2025-02-26

申请号：EP23936793.1

申请日：2023-11-27

Applicant: Shanxi Jinbo Bio-Pharmaceutical Co., Ltd.

Inventor： YANG, Xia ,  LAN, Xiaobin ,  WANG, Lingling ,  ZHANG, Yongjian ,  LIU, Xin ,  LIU, Zengyao ,  YANG, Wenfei

IPC: C07K14/78 ,  C12N15/70 ,  C12N15/12 ,  C12N1/21 ,  A61K38/39 ,  A61P19/08 ,  C12N5/077 ,  C12R1/19

Abstract: Provided is collagen and uses thereof. Collagen includes an N-terminal sequence and a C-terminal sequence, wherein the N-terminal sequence includes one or more repeating units, and the repeating unit includes an amino acid sequence shown in SEQ ID NO. 15. The recombinant type II humanized collagen prepared by the present invention has high activity in promoting cell adhesion, does not produce an immune response when applied to the human body, can be obtained on a large scale, and is expected to be widely used in the field of cartilage repair.

公开(公告)号：EP4511490A1

公开(公告)日：2025-02-26

申请号：EP23792490.7

申请日：2023-04-19

Applicant: The Administrators of The Tulane Educational Fund

Inventor： BROOKS, Rani

IPC: C12N15/52 ,  C12N1/20 ,  C12N9/22 ,  C12N15/113 ,  C12N15/70

公开(公告)号：EP4486895A1

公开(公告)日：2025-01-08

申请号：EP23709620.1

申请日：2023-03-02

Applicant: Gen-H Genetic Engineering Heidelberg GmbH

Inventor： KRANZ, Harald ,  SCHMIDT, Marlen ,  BRECHUN, Katherine Emily ,  FÖRSCHLE, Marion

IPC: C12N15/64 ,  C12N15/68 ,  C12N15/63 ,  C12N15/70

公开(公告)号：EP4481038A1

公开(公告)日：2024-12-25

申请号：EP23756588.2

申请日：2023-02-14

Applicant: Daesang Corporation

Inventor： KIM, Hyun Young ,  YANG, Cheol Min ,  SHIN, Won Joo ,  KIM, Yong Soo ,  JO, Young Il

IPC: C12N9/02 ,  C07K14/245 ,  C12N15/70 ,  C12P13/22

Abstract: The present invention relates to a novel stress protein variant and a method of producing an L-aromatic amino acid using the same. The stress protein variant is obtained by substituting one or more amino acids in the amino acid sequence constituting glutathione reductase or stress protein B to change the activity of the protein, and a recombinant microorganism comprising the variant is capable of efficiently producing an L-aromatic amino acid.

公开(公告)号：EP4444888A2

公开(公告)日：2024-10-16

申请号：EP22905013.3

申请日：2022-12-06

Applicant: Cornell University

Inventor： GUO, Chun-Jun ,  JIN, Wenbing ,  LI, Tingting

IPC: C12N15/74 ,  C12N15/11 ,  C12N15/70

公开(公告)号：EP4438732A1

公开(公告)日：2024-10-02

申请号：EP23904796.2

申请日：2023-04-07

Applicant: Daesang Corporation

Inventor： CHOI, Eun Seok ,  LEE, Ji Ha

IPC: C12N15/70 ,  C12N9/90 ,  C12P19/02

CPC classification number: C12N9/90 ,  C12P19/02 ,  C12N15/70

Abstract: The present disclosure provides a novel promoter variant in which some nucleotides are inserted, deleted, or substituted in a twin arginine translocase A (tatA) gene promoter of Escherichia coli. According to the present disclosure, the novel promoter variant can constitutively high-express a target protein, particularly an enzyme, in Escherichia coli. Therefore, by using a recombinant strain transformed with an expression vector including the novel promoter variant according to the present disclosure, it is possible to economically mass-produce a target protein, particularly an enzyme. For example, by using a recombinant strain transformed with an expression vector including the novel promoter variant according to the present disclosure, it is possible to economically mass-produce allulose epimerase or economically mass-produce allulose from fructose.

公开(公告)号：EP4436668A1

公开(公告)日：2024-10-02

申请号：EP22896880.6

申请日：2022-11-25

Applicant: The Westmead Institute For Medical Research ,  Western Sydney Local Health District

Inventor： KAMRUZZAMAN, Muhammad ,  IREDELL, Jonathan

IPC: A61P31/04 ,  C12N1/20 ,  C12N15/70 ,  C12N15/74

CPC classification number: C12N15/70 ,  C12N15/74 ,  A61P31/04 ,  C07K14/195 ,  C07K14/245 ,  C12R2001/0120210501 ,  C12R2001/1920210501 ,  C07K14/24 ,  C12R2001/2220210501 ,  C12R2001/4220210501

公开(公告)号：EP4206220B1

公开(公告)日：2024-10-02

申请号：EP20953153.2

申请日：2020-12-24

IPC: C07K14/62 ,  C12N15/11 ,  A61K38/00 ,  C12N15/70 ,  C12P21/06

CPC classification number: C12N15/70 ,  C07K14/62 ,  Y02A50/30 ,  A61K38/00 ,  C12P21/06

公开(公告)号：EP4430195A2

公开(公告)日：2024-09-18

申请号：EP22893870.0

申请日：2022-11-11

Applicant: Georgia Tech Research Corporation

Inventor： BLAZECK, John, James ,  JENNINGS, Maria, Rain

IPC: C12N15/52 ,  A61K38/50 ,  A61P35/00 ,  C12N15/70 ,  C12N15/85 ,  C12N9/78

CPC classification number: C12N9/78