- 专利标题： NUCLEIC ACID MOLECULE FOR INDUCTION OF ASYMMETRIC RNAI FOR INHIBITING EXPRESSION OF ROR-BETA
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申请号： EP21903785.0申请日： 2021-12-06
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公开(公告)号： EP4257686A1公开(公告)日： 2023-10-11
- 发明人: CHUNG, Hye Won , PARK, June Hyun , YANG, Seung Ya
- 申请人： OliX Pharmaceuticals, Inc.
- 申请人地址： KR Gyeonggi-do 16226 1014, Gwanggyo Ace Tower 1 17, Daehak 4-ro, Yeongtong-gu, Suwon-si,
- 代理机构： Weickmann & Weickmann PartmbB
- 优先权： KR20200169855 20201207
- 国际公布： WO2022124739 20220616
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K31/7088 ; A61P27/02
摘要：
The present application relates to an asymmetric RNAi-inducing nucleic acid molecule which inhibits the expression of retinoid-related orphan nuclear receptor-beta (ROR-beta) and use thereof, and more particularly to an asymmetric RNAi-inducing nucleic acid molecule comprising an antisense strand comprising a sequence complementary to mRNA encoding ROR-beta, and a sense strand forming complementary bonds with the antisense strand, and a pharmaceutical composition for ameliorating or treating a retinal disease, comprising the asymmetric RNAi-inducing nucleic acid molecule.
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