- 专利标题： THYROID HORMONE RECEPTOR BETA SELECTIVE AGONIST COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
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申请号： EP21905628.0申请日： 2021-12-10
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公开(公告)号： EP4265609A1公开(公告)日： 2023-10-25
- 发明人: ZHOU, Bing , LENG, Ying , YANG, Yaxi , NING, Mengmeng , HU, Liuyu , FENG, Lei , LIANG, Ju
- 申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 申请人地址： CN Pudong, Shanghai 201203 555 Zu Chong Zhi Road Zhang Jiang
- 代理机构： Grünecker Patent- und Rechtsanwälte PartG mbB
- 优先权： CN202111482622 20211207
- 国际公布： WO2022127699 20220623
- 主分类号： C07D403/10
- IPC分类号： C07D403/10 ; C07D403/12 ; A61K31/53 ; A61P5/16
摘要：
The present invention relates to a thyroid hormone receptor β selective agonist compound represented by formula I, a pharmaceutical composition and use thereof. The compound improves the selectivity to THR-α and the druggability of the compound while maintaining good THR-β agonistic activity, and shows a certain activity in in vivo pharmacological experiments.
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