公开(公告)号：EP4265609A1

公开(公告)日：2023-10-25

申请号：EP21905628.0

申请日：2021-12-10

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： ZHOU, Bing ,  LENG, Ying ,  YANG, Yaxi ,  NING, Mengmeng ,  HU, Liuyu ,  FENG, Lei ,  LIANG, Ju

IPC分类号： C07D403/10 ,  C07D403/12 ,  A61K31/53 ,  A61P5/16

摘要： The present invention relates to a thyroid hormone receptor β selective agonist compound represented by formula I, a pharmaceutical composition and use thereof. The compound improves the selectivity to THR-α and the druggability of the compound while maintaining good THR-β agonistic activity, and shows a certain activity in in vivo pharmacological experiments.

公开(公告)号：EP2199295A1

公开(公告)日：2010-06-23

申请号：EP07721682.8

申请日：2007-05-29

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： SHEN, Jianhua ,  LENG, Ying ,  JIANG, Hualiang ,  CHEN, Junhua

IPC分类号： C07D513/14 ,  C07D498/14 ,  C07D497/14 ,  C07D495/14 ,  C07D493/14 ,  C07D487/14 ,  C07D487/04 ,  C07D243/38 ,  C07D321/10 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00

CPC分类号： C07D243/38 ,  C07D243/14 ,  C07D267/20 ,  C07D281/16 ,  C07D321/10 ,  C07D405/12 ,  C07D487/04 ,  C07D487/14 ,  C07D493/14 ,  C07D495/14 ,  C07D497/14 ,  C07D498/14 ,  C07D513/14

摘要： The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.

摘要翻译： 本发明光盘失去在糖尿病和代谢综合征的预防和治疗式蒸发散的制备的新用途的一类化合物七环的; 因此，本发明光盘松一类新的七环化合物; 因此，本发明光盘松用于制备七环化合物和含有其的组合物的方法。 本发明的七环化合物可用于有效预防或治疗疾病：如糖尿病和代谢综合征。