发明公开
- 专利标题： USE OF THE CD2 SIGNALING DOMAIN IN SECOND-GENERATION CHIMERIC ANTIGEN RECEPTORS
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申请号： EP23193203.9申请日： 2013-02-22
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公开(公告)号： EP4275699A2公开(公告)日： 2023-11-15
- 发明人: JUNE, Carl H. , SCHOLLER, John , POSEY, Avery D.
- 申请人： The Trustees of the University of Pennsylvania
- 申请人地址： US Philadelphia PA 19104-6283 3600 Civic Center Boulevard, 9th Floor
- 代理机构： Grünecker Patent- und Rechtsanwälte PartG mbB
- 优先权： US201261601907 P 20120222
- 主分类号： A61K39/00
- IPC分类号： A61K39/00
摘要：
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions.
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