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公开(公告)号：EP4275699A2
公开(公告)日：2023-11-15
申请号：EP23193203.9
申请日：2013-02-22
发明人： JUNE, Carl H. , SCHOLLER, John , POSEY, Avery D.
IPC分类号： A61K39/00
摘要： The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions.
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公开(公告)号：EP3174546B1
公开(公告)日：2019-10-30
申请号：EP15753252.4
申请日：2015-07-31
IPC分类号： C07K16/28 , A61K39/00 , A61K35/17 , C07K14/705 , A61K39/395 , A61K31/436 , C07K14/725 , C12N5/0783
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公开(公告)号：EP3947471A1
公开(公告)日：2022-02-09
申请号：EP20776961.3
申请日：2020-03-26
发明人： POSEY, Avery D. , JUNE, Carl H.
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公开(公告)号：EP4205749A1
公开(公告)日：2023-07-05
申请号：EP22210490.3
申请日：2015-07-31
IPC分类号： A61K35/17 , C07K14/705 , A61K31/436 , A61K39/00 , A61K39/395 , C07K14/725 , C07K16/28 , C12N5/0783
摘要： This disclosure provides, for instance subset-optimized CART cells and related methods. For instance, the disclosure describes methods and compositions of CD4 + and CD8 + T cells that express CARs containing specific combinations of intracellular signaling domains can be used to increase persistence and anti-tumor activity of the infused CAR-expressing T cells for treating a subject having a disease, e.g., a cancer.
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5.发明公开
公开(公告)号：EP3898692A1
公开(公告)日：2021-10-27
申请号：EP19898610.1
申请日：2019-12-19
发明人： RUELLA, Marco , GILL, Saar , JUNE, Carl H. , POSEY, Avery D. , POWELL, Daniel J.
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公开(公告)号：EP3174546A1
公开(公告)日：2017-06-07
申请号：EP15753252.4
申请日：2015-07-31
IPC分类号： A61K35/17 , C07K14/705
摘要： This disclosure provides, for instance subset-optimized CART cells and related methods. For instance, the disclosure describes methods and compositions of CD4′ and CD8′ T cells that express CARs containing specific combinations of intracellular signaling domains can be used to increase persistence and anti-tumor activity of the infused CAR-expressing T cells for treating a subject having a disease, e.g., a cancer.
摘要翻译： 本公开提供了例如子集优化的CART单元和相关方法。 例如，本公开内容描述了表达CAR的CD4 +和CD8 + T细胞的方法和组合物，其中含有细胞内信号传导结构域的特定组合可用于增加注入的表达CAR的T细胞的持久性和抗肿瘤活性，用于治疗患有 疾病，例如癌症。
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公开(公告)号：EP4275699A3
公开(公告)日：2024-01-03
申请号：EP23193203.9
申请日：2013-02-22
发明人： JUNE, Carl H. , SCHOLLER, John , POSEY, Avery D.
IPC分类号： C07K14/705 , C07K16/28 , C07K16/30 , C12N15/85 , C07K14/725 , A61P35/00 , A61K39/00 , A61P37/04 , A61P43/00
摘要： The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions.
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8.发明公开
公开(公告)号：EP3781176A1
公开(公告)日：2021-02-24
申请号：EP19785427.6
申请日：2019-04-08
发明人： POWELL, Daniel J. , SMOLE, Anze , POSEY, Avery D. , O'ROURKE, Donald , YIN, Yibo , JUNE, Carl , ROMMEL, Philipp
IPC分类号： A61K35/17 , A61K48/00 , C07K14/435 , C07K14/705 , C07K16/00 , C07K16/28
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公开(公告)号：EP3660042A1
公开(公告)日：2020-06-03
申请号：EP19199959.8
申请日：2015-07-31
IPC分类号： C07K14/705 , A61K35/17 , A61K31/436 , A61K39/00 , A61K39/395 , C07K14/725 , C07K16/28 , C12N5/0783
摘要： This disclosure provides, for instance subset-optimized CART cells and related methods. For instance, the disclosure describes methods and compositions of CD4 + and CD8 + T cells that express CARs containing specific combinations of intracellular signaling domains can be used to increase persistence and anti-tumor activity of the infused CAR-expressing T cells for treating a subject having a disease, e.g., a cancer.
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