- 专利标题： INTERMEDIATES TO OBTAIN SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
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申请号： EP23190105.9申请日： 2012-12-28
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公开(公告)号： EP4289813A3公开(公告)日： 2024-05-15
- 发明人: METCALF, Brian , CHUANG, Chihyuan , WARRINGTON, Jeffrey , PAULVANNAN, Kumar , JACOBSON, Matthew , HUA, Lan , MORGAN, Bradley
- 申请人： Global Blood Therapeutics, Inc.
- 申请人地址： US South San Francisco, CA 94080 181 Oyster Point Blvd.
- 专利权人： Global Blood Therapeutics, Inc.
- 当前专利权人： Global Blood Therapeutics, Inc.
- 当前专利权人地址： US South San Francisco, CA 94080 181 Oyster Point Blvd.
- 代理机构： J A Kemp LLP
- 优先权： US 201161581053 P 2011.12.28
- 分案原申请号： 20167746.5 2020.04.02;16194019.2 2016.10.14;12862525.8 2012.12.28
- 主分类号： A01N35/00
- IPC分类号： A01N35/00 ; A61K31/11 ; C07D213/80 ; C07D215/14 ; C07C69/76 ; C07D231/56 ; C07D401/04 ; C07D471/04 ; C07D257/04 ; C07D487/04 ; C07D211/62 ; C07D213/30 ; C07C65/21
摘要：
Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
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