公开(公告)号：EP4289813A3

公开(公告)日：2024-05-15

申请号：EP23190105.9

申请日：2012-12-28

Applicant: Global Blood Therapeutics, Inc.

Inventor： METCALF, Brian ,  CHUANG, Chihyuan ,  WARRINGTON, Jeffrey ,  PAULVANNAN, Kumar ,  JACOBSON, Matthew ,  HUA, Lan ,  MORGAN, Bradley

IPC: A01N35/00 ,  A61K31/11 ,  C07D213/80 ,  C07D215/14 ,  C07C69/76 ,  C07D231/56 ,  C07D401/04 ,  C07D471/04 ,  C07D257/04 ,  C07D487/04 ,  C07D211/62 ,  C07D213/30 ,  C07C65/21

CPC classification number: C07D213/80 ,  C07D231/56 ,  C07D401/04 ,  C07D257/04 ,  C07D211/62 ,  C07D213/30 ,  C07C69/76 ,  C07C65/30 ,  A61K31/192 ,  A61K31/235 ,  A61K31/41 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/47 ,  A61K31/4985 ,  C07D471/04 ,  A61P1/00 ,  A61P1/04 ,  A61P11/00 ,  A61P17/00 ,  A61P17/02 ,  A61P25/00 ,  A61P25/28 ,  A61P31/00 ,  A61P31/14 ,  A61P35/00 ,  A61P43/00 ,  A61P7/00 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  Y02P20/55

Abstract: Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

公开(公告)号：EP4258056A3

公开(公告)日：2024-02-28

申请号：EP23192171.9

申请日：2021-12-22

Applicant: SHIN-ETSU CHEMICAL CO., LTD.

Inventor： INOUE, Naoya ,  WATANABE, Satoshi ,  KOTAKE, Masaaki

IPC: C07C43/23 ,  C07C69/44 ,  C07C69/712 ,  C07C69/76 ,  C07C69/82 ,  C08L33/26 ,  C08L33/16

Abstract: A chemically amplified negative resist composition comprising an alcohol compound of specific structure as a crosslinker has a high sensitivity and dissolution contrast and forms a pattern of good profile with reduced values of LER and CDU.

公开(公告)号：EP4267122A1

公开(公告)日：2023-11-01

申请号：EP21909683.1

申请日：2021-12-22

Applicant: Buzzelet Development And Technologies Ltd

Inventor： EYAL, Aharon

IPC: A61K31/192 ,  A61K31/05 ,  C07C69/76

公开(公告)号：EP4107143A1

公开(公告)日：2022-12-28

申请号：EP21711678.9

申请日：2021-02-18

Applicant: Dow Global Technologies LLC ,  Rohm and Haas Company

Inventor： BISWAS, Souvagya ,  FIGUEROA, Ruth ,  SATHIOSATHAM, Muhunthan

IPC: C07C67/313 ,  C07C69/76

公开(公告)号：EP3907215A1

公开(公告)日：2021-11-10

申请号：EP19908010.2

申请日：2019-01-02

Applicant: Linhai Huanan Chemical Co., Ltd. ,  Zhejiang Huahai Pharmaceutical Co., Ltd.

Inventor： TU, Guoliang ,  HUANG, Jiansheng ,  ZHANG, Lu ,  YANG, Tao ,  LIANG, Zunjun

IPC: C07C67/30 ,  C07C69/76

Abstract: A synthesis method for a candesartan cilexetil intermediate represented by formula (II). The method comprises: (1) dissolving a compound represented by formula (IV) to an aprotic solvent to obtain a first mixed solution, and dissolving a phase transfer catalyst and an azidation reagent to water to obtain a second mixed solution; (2) dropping the first mixed solution to the second mixed solution for azidation reaction, and after the reaction is ended, standing and layering same to obtain an organic phase containing a compound represented by formula (V); (3) dropping the obtained organic phase containing the compound represented by formula (V) to tertiary butyl alcohol for rearrangement reaction, and after the reaction is ended, concentrating same to obtain a solid or oily material, then adding a crystallizing solvent to the obtained solid or oily material for recrystallization, and separating same to obtain a crystal, i.e., the candesartan cilexetil intermediate represented by formula (II). The synthesis method of the present application does not require the use of a DMF solvent, is safe and environmentally friendly, and reduces generation of ammonia nitrogen wastewater.

公开(公告)号：EP3887374A2

公开(公告)日：2021-10-06

申请号：EP19827939.0

申请日：2019-11-27

Applicant: Teva Pharmaceuticals International GmbH

Inventor： JANTON, Nikolina ,  CERIC, Helena ,  MATESIC MUSANIC, Sanja ,  MRSIC, Natasa ,  LERMAN, Lidija ,  MOMCILOVIC, Tina Dancevic ,  SAGUD, Ivana ,  JEGOROV, Alexandr

IPC: C07D471/16 ,  C07D471/04 ,  C07C309/29 ,  C07C309/30 ,  C07C59/50 ,  C07C69/76 ,  A61P25/00 ,  A61K31/4985

公开(公告)号：EP3480191B1

公开(公告)日：2021-09-01

申请号：EP17820299.0

申请日：2017-06-29

Inventor： MORIGUCHI, Hideki ,  TANAKA, Yusuke ,  INO, Tatsunori ,  KAMBE, Tohru ,  NISHIYAMA, Taihei ,  TSUJIYAMA, Shinichiro ,  UEDA, Yohei

IPC: C07D313/06 ,  C07C69/65 ,  C07C69/76 ,  C07D307/935 ,  C07B61/00

公开(公告)号：EP3093270B1

公开(公告)日：2021-09-01

申请号：EP15735309.5

申请日：2015-01-08

Inventor： BAE, Jaesoon ,  LEE, Jaechol ,  LEE, Jiyoung ,  CHOI, Doowhan

IPC: C01B32/156 ,  C09K11/65 ,  H01L51/42 ,  H01L51/50 ,  C07C69/157 ,  C07C69/24 ,  C07C69/42 ,  C07C69/54 ,  C07C69/612 ,  C07C69/708 ,  C07C69/716 ,  C07C69/738 ,  C07C69/757 ,  C07C69/76 ,  C07C69/78 ,  C07D333/38 ,  C07C211/00 ,  C07C229/42 ,  C07C69/618 ,  B82Y30/00 ,  B82Y40/00

公开(公告)号：EP3619188B1

公开(公告)日：2020-10-07

申请号：EP18749310.1

申请日：2018-07-16

Applicant: Lonza Ltd

Inventor： BERSIER, Michael ,  KULESZA, Anna ,  HANSELMANN, Paul ,  AELLIG, Christof ,  FILLIGER, Sarah

IPC: C07C67/08 ,  C07C69/76 ,  C07C201/08 ,  C07C63/04

公开(公告)号：EP3687512A1

公开(公告)日：2020-08-05

申请号：EP18792980.7

申请日：2018-10-01

Applicant: Universite Paris-Sud ,  Centre National de la Recherche Scientifique (CNRS) ,  Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Institut Gustave Roussy

Inventor： MESSAOUDI, Samir ,  ALAMI, Mouad ,  BRION, Jean-Daniel ,  CHABRIER, Amélie ,  TELERMAN, Adam ,  AMSON, Robert

IPC: A61K31/015 ,  A61K31/03 ,  A61K31/085 ,  A61K31/165 ,  A61K31/235 ,  A61K31/24 ,  A61K31/353 ,  A61K31/382 ,  A61K31/404 ,  A61K31/7036 ,  A61K31/706 ,  A61P35/02 ,  A61P33/06 ,  C07D311/20 ,  C07H13/08 ,  C07H15/203 ,  C07D209/08 ,  C07D335/06 ,  C07C69/76 ,  C07C211/38 ,  C07C233/10