- 专利标题： A COMPOSITION FOR USE IN THE THERAPEUTIC TREATMENT OF A CANCER OR A TUMOR
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申请号： EP23171081.5申请日： 2017-01-05
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公开(公告)号： EP4349410A3公开(公告)日： 2024-06-05
- 发明人: IAVARONE, Antonio , LASORELLA, Anna
- 申请人： The Trustees Of Columbia University In The City Of New York
- 申请人地址： US New York, NY 10027 412 Low Memorial Library 535 W. 116th Street
- 专利权人： The Trustees Of Columbia University In The City Of New York
- 当前专利权人： The Trustees Of Columbia University In The City Of New York
- 当前专利权人地址： US New York, NY 10027 412 Low Memorial Library 535 W. 116th Street
- 代理机构： Berggren Oy
- 优先权： US 201662274871 P 2016.01.05
- 分案原申请号： 17736345.4 2017.01.05
- 主分类号： A61K38/45
- IPC分类号： A61K38/45 ; A61K38/44 ; A61K38/19 ; A61K48/00 ; C12N15/63 ; C12N5/10 ; C12N15/12 ; C12N9/12 ; A61P35/00 ; A61K45/06
摘要：
The present disclosure provides a composition for use in the therapeutic treatment of a cancer or a tumor in a patient, said composition comprising an isolated Dual-Specificity Tyrosine-Phosphorylation-Regulated Protein Kinase 1 (DYRK1) protein and isolated prolyl hydroxylase (PHD) protein, wherein the composition increases degradation of Hypoxia-Inducible Factor-α (HIFα) in cancer cells or tumor cells in the patient and/or decreases half-life of HIFα in the cancer cells or the tumor cells in the patient.
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