发明公开
- 专利标题: NOVEL GLP-1 ANALOGUES
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申请号: EP24161843.8申请日: 2019-04-05
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公开(公告)号: EP4364751A2公开(公告)日: 2024-05-08
- 发明人: THENNATI, Rajamannar , CHATURVEDI, Nishith , BURADE, Vinod Sampatrao , SHAHI, Pradeep Dinesh , NATARAJAN, Muthukumaran , NAGARAJA, Ravishankara Madavati , ZALAWADIA, Rishit Mansukhlal , PANDYA, Kunal , PATEL, Brijeshkumar , JOSHI, Dhiren Rameshchandra , SONI, Krunal Harishbhai , TIWARI, Abhishek , PATEL, Vipulkumar Shankarbhai
- 申请人: Sun Pharmaceutical Industries Limited
- 申请人地址: IN Mumbai, Maharashtra 400 063 Sun House Plot No. 201 B/1 Western Express Highway Goregaon (E)
- 专利权人: Sun Pharmaceutical Industries Limited
- 当前专利权人: Sun Pharmaceutical Industries Limited
- 当前专利权人地址: IN Mumbai, Maharashtra 400 063 Sun House Plot No. 201 B/1 Western Express Highway Goregaon (E)
- 代理机构: HGF
- 优先权: IN 201821013109 2018.04.05
- 分案原申请号: 22177403.7 2022.06.06;19724915.4 2019.04.05
- 主分类号: A61K38/26
- IPC分类号: A61K38/26
摘要:
The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.
公开/授权文献
- EP4364751A3 NOVEL GLP-1 ANALOGUES 公开/授权日:2024-06-26
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