发明公开
- 专利标题： NOVEL SPIROBICYCLIC ANALOGUES
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申请号： EP24162318.0申请日： 2018-12-06
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公开(公告)号： EP4385996A3公开(公告)日： 2024-07-31
- 发明人: VERHOEVEN, Jonas , VERNIEST, Guido Alfons F. , THURING, Johannes Wilhelmus John F. , WU, Tongfei , PANDE, Vineet , MEERPOEL, Lieven , BREHMER, Dirk , SUN, Weimei , DENMARK, Scott E.
- 申请人： JANSSEN Pharmaceutica NV
- 申请人地址： BE 2340 Beerse Turnhoutseweg 30
- 专利权人： JANSSEN Pharmaceutica NV
- 当前专利权人： JANSSEN Pharmaceutica NV
- 当前专利权人地址： BE 2340 Beerse Turnhoutseweg 30
- 代理机构： Lenaerts, Philip
- 优先权： US 1762596441P 2017.12.08
- 分案原申请号： 18816013.9 2018.12.06
- 主分类号： C07H19/14
- IPC分类号： C07H19/14 ; C07D471/04 ; A61K31/505 ; A61P35/00
摘要：
The present invention relates to novel spirobicyclic analogues of Formula (I)
wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
公开/授权文献
- EP4385996A2 NOVEL SPIROBICYCLIC ANALOGUES 公开/授权日：2024-06-19
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