公开(公告)号：EP4385996A2

公开(公告)日：2024-06-19

申请号：EP24162318.0

申请日：2018-12-06

申请人： JANSSEN Pharmaceutica NV

发明人： VERHOEVEN, Jonas ,  VERNIEST, Guido Alfons F. ,  THURING, Johannes Wilhelmus John F. ,  WU, Tongfei ,  PANDE, Vineet ,  MEERPOEL, Lieven ,  BREHMER, Dirk ,  SUN, Weimei ,  DENMARK, Scott E.

IPC分类号： C07H19/167

CPC分类号： C07D307/94 ,  C07D317/44 ,  C07H19/14 ,  C07D471/04 ,  A61P35/00 ,  C07H19/167

摘要： The present invention relates to novel spirobicyclic analogues of Formula (I)

wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

公开(公告)号：EP4385996A3

公开(公告)日：2024-07-31

申请号：EP24162318.0

申请日：2018-12-06

申请人： JANSSEN Pharmaceutica NV

发明人： VERHOEVEN, Jonas ,  VERNIEST, Guido Alfons F. ,  THURING, Johannes Wilhelmus John F. ,  WU, Tongfei ,  PANDE, Vineet ,  MEERPOEL, Lieven ,  BREHMER, Dirk ,  SUN, Weimei ,  DENMARK, Scott E.

IPC分类号： C07H19/14 ,  C07D471/04 ,  A61K31/505 ,  A61P35/00

CPC分类号： C07D307/94 ,  C07D317/44 ,  C07H19/14 ,  C07D471/04 ,  A61P35/00 ,  C07H19/167

摘要： The present invention relates to novel spirobicyclic analogues of Formula (I)

wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.