- 专利标题： HUMAN INTERLEUKIN 2-POLYETHYLENE GLYCOL CONJUGATE AND USE THEREOF
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申请号： EP22863257.6申请日： 2022-08-24
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公开(公告)号： EP4397677A1公开(公告)日： 2024-07-10
- 发明人: LIANG, Xuejun , YE, Chenghao , XIA, Gang , CHEN, Longfei , HUO, Pengchao , YANG, Jinwei , YING, Yuebin , GONG, Zunyang , HENG, Xin , ZHU, Xiaoyu , ZHU, Lifei , HUANG, Hao , DING, Wen , JIAO, Lin , ZHU, Jingjing
- 申请人： Novocodex Biopharmaceuticals Co., Ltd.
- 申请人地址： CN Shaoxing, Zhejiang 312366 No.502, Fl.5, Buiding C, high-tech venture park 398 Mahuan Road, Yuecheng District
- 专利权人： Novocodex Biopharmaceuticals Co., Ltd.
- 当前专利权人： Novocodex Biopharmaceuticals Co., Ltd.
- 当前专利权人地址： CN Shaoxing, Zhejiang 312366 No.502, Fl.5, Buiding C, high-tech venture park 398 Mahuan Road, Yuecheng District
- 代理机构： Aera A/S
- 优先权： CN 2111019771 2021.09.01
- 国际申请： CN2022114421 2022.08.24
- 国际公布： WO2023030118 2023.03.09
- 主分类号： C07K14/55
- IPC分类号： C07K14/55 ; A61K38/20 ; A61K47/60 ; A61P35/00 ; A61P35/02 ; A61P37/04
摘要：
A human interleukin 2-polyethylene glycol conjugate and use thereof. The human interleukin 2-polyethylene glycol conjugate comprises a recombinant human interleukin 2 containing at least one unnatural amino acid and PEG coupled to the at least one unnatural amino acid. The unnatural amino acid is a compound containing a carbonyl terminal group and having a structure as shown in formula (I) or an enantiomer thereof, and the PEG is coupled to the at least one unnatural amino acid by forming an oxime bond between the carbonyl terminal group and the PEG containing a hydroxylamine terminal group. The human interleukin 2-polyethylene glycol conjugate can be used individually or in combination with other anti-tumor drugs for the treatment of diseases such as solid tumors and hematologic tumors.
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