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1.发明公开
公开(公告)号：EP4378926A1
公开(公告)日：2024-06-05
申请号：EP21951293.6
申请日：2021-07-29
发明人： YANG, Jinwei , YE, Chenghao , XIA, Gang , HUO, Pengchao , DING, Wen , CHEN, Longfei , JIAO, Lin , HUANG, Hao , HENG, Xin , ZHU, Jingjing , YING, Yuebin , LIANG, Xuejun
IPC分类号： C07C271/22 , C07C235/78 , C07C237/12 , C07C235/20 , C07K14/61 , A61K47/54 , A61K47/60 , A61K38/27 , A61P5/06
CPC分类号： A61K38/27 , A61K47/54 , A61K47/60 , A61P5/06 , C07C235/20 , C07C235/78 , C07C237/12 , C07C271/22 , C07K14/61
摘要： The invention provides an unnatural amino acid, which is a compound with a structure as shown in formula (I) or an enantiomer thereof. The invention further provides use of the unnatural amino acid. Furthermore, the invention further provides a recombinant protein containing the unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid provided by the invention is simple and convenient to prepare, safe in nature, not easy to be inactivated when being inserted into a protein, and has a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid provided by the invention is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate,
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公开(公告)号：EP4397677A1
公开(公告)日：2024-07-10
申请号：EP22863257.6
申请日：2022-08-24
发明人： LIANG, Xuejun , YE, Chenghao , XIA, Gang , CHEN, Longfei , HUO, Pengchao , YANG, Jinwei , YING, Yuebin , GONG, Zunyang , HENG, Xin , ZHU, Xiaoyu , ZHU, Lifei , HUANG, Hao , DING, Wen , JIAO, Lin , ZHU, Jingjing
CPC分类号： Y02A50/30
摘要： A human interleukin 2-polyethylene glycol conjugate and use thereof. The human interleukin 2-polyethylene glycol conjugate comprises a recombinant human interleukin 2 containing at least one unnatural amino acid and PEG coupled to the at least one unnatural amino acid. The unnatural amino acid is a compound containing a carbonyl terminal group and having a structure as shown in formula (I) or an enantiomer thereof, and the PEG is coupled to the at least one unnatural amino acid by forming an oxime bond between the carbonyl terminal group and the PEG containing a hydroxylamine terminal group. The human interleukin 2-polyethylene glycol conjugate can be used individually or in combination with other anti-tumor drugs for the treatment of diseases such as solid tumors and hematologic tumors.
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3.发明公开
公开(公告)号：EP4378925A1
公开(公告)日：2024-06-05
申请号：EP21951294.4
申请日：2021-07-29
发明人： YANG, Jinwei , YE, Chenghao , XIA, Gang , HUO, Pengchao , DING, Wen , CHEN, Longfei , JIAO, Lin , HUANG, Hao , HENG, Xin , ZHU, Jingjing , YING, Yuebin , LIANG, Xuejun
IPC分类号： C07C269/00 , C07C269/06 , C07C271/22 , C07C231/12 , C07C235/74 , C07D233/56 , C07D207/46 , C07C51/41 , C07C53/18 , C07C201/12 , C07C205/43 , C07C41/16 , C07C43/178 , C07K14/61 , A61K38/27 , A61K47/60 , A61K47/68 , A61P5/06 , A61P35/00
CPC分类号： A61K38/27 , A61K47/60 , A61K47/68 , A61P5/06 , A61P35/00 , C07C41/16 , C07C43/178 , C07C51/41 , C07C53/18 , C07C201/12 , C07C205/43 , C07C231/12 , C07C235/74 , C07C269/00 , C07C269/06 , C07C271/22 , C07D207/46 , C07D233/56 , C07K14/61
摘要： The invention provides an unnatural amino acid, which is a compound with a structure as shown in formula (I) or an enantiomer thereof. The invention further provides use of the unnatural amino acid. Furthermore, the invention further provides a recombinant protein containing the unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid provided by the invention is simple and convenient to prepare, safe in nature, not easy to be inactivated when being inserted into a protein, and has a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid provided by the invention is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate,
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