- 专利标题： BISPECIFIC ANTIBODY TO A-SYN/IGF1R AND USE THEREOF
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申请号： EP24170761.1申请日： 2018-12-14
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公开(公告)号： EP4403218A3公开(公告)日： 2024-11-06
- 发明人: AHN, Jinhyung , AN, Sungwon , KIM, Dongin , SUNG, Eunsil , EOM, Jaehyun , LEE, Sang Hoon , YOU, Weonkyoo , KIM, Juhee , PARK, Kyungjin , CHUNG, Hyejin , JUNG, Jinwon , LEE, Bora , SUNG, Byungje , KIM, Yeunju , SON, Yong-Gyu , AHN, Seawon , SONG, Daehae , YOO, Jiseon , PAK, Youngdon , YEOM, Donghoon , LEE, Yoseob , JUNG, Jaeho
- 申请人： ABL Bio, Inc.
- 申请人地址： KR Seongnam-si, Gyeonggi-do 13488 2F, 16, Daewangpangyo-ro 712 beon-gil Bundang-gu
- 代理机构： Zwicker, Jörk
- 优先权： US201862734388 P 20180921
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/18 ; A61P25/16 ; A61P25/00
摘要：
The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and use of the bi-specific antibody for treating or diagnosing synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates. The IGF1R portion of the bi-specific antibody acts as a shuttle to penetrate the blood brain barrier, allowing the alpha-synuclein portion to exert its action in the brain. Further, the half-life of the bi-specific antibody may be extended to maintain efficacy over time.
公开/授权文献
- EP4403218A2 BISPECIFIC ANTIBODY TO A-SYN/IGF1R AND USE THEREOF 公开/授权日：2024-07-24
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