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公开(公告)号：EP4403218A2
公开(公告)日：2024-07-24
申请号：EP24170761.1
申请日：2018-12-14
申请人： ABL Bio, Inc.
发明人： AHN, Jinhyung , AN, Sungwon , KIM, Dongin , SUNG, Eunsil , EOM, Jaehyun , LEE, Sang Hoon , YOU, Weonkyoo , KIM, Juhee , PARK, Kyungjin , CHUNG, Hyejin , JUNG, Jinwon , LEE, Bora , SUNG, Byungje , KIM, Yeunju , SON, Yong-Gyu , AHN, Seawon , SONG, Daehae , YOO, Jiseon , PAK, Youngdon , YEOM, Donghoon , LEE, Yoseob , JUNG, Jaeho
IPC分类号： A61P25/00
CPC分类号： C07K16/2863 , C07K16/18 , C07K2317/3120130101 , C07K2317/9420130101 , C07K2317/9220130101 , C07K2317/7720130101 , A61P25/16 , C07K2317/2120130101 , C07K2317/2420130101 , C07K2317/3420130101 , C07K2317/3520130101 , C07K2317/52620130101 , C07K2317/56520130101 , C07K2317/62220130101 , C07K2317/3320130101 , A61K2039/50520130101 , A61P25/00
摘要： The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and use of the bi-specific antibody for treating or diagnosing synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates. The IGF1R portion of the bi-specific antibody acts as a shuttle to penetrate the blood brain barrier, allowing the alpha-synuclein portion to exert its action in the brain. Further, the half-life of the bi-specific antibody may be extended to maintain efficacy over time.
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公开(公告)号：EP4048699A1
公开(公告)日：2022-08-31
申请号：EP20889266.1
申请日：2020-11-23
申请人： ABL Bio Inc. , I-MAB
发明人： SUNG, Eunsil , PARK, Eunyoung , JEON, Jaehyoung , JEONG, Junhyun , SONG, Daehae , LEE, Sunju , FANG, Lei , JIANG, Wenqing , CUI, Feifei
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公开(公告)号：EP4004053A1
公开(公告)日：2022-06-01
申请号：EP20848658.9
申请日：2020-07-27
申请人： ABL Bio, Inc. , Yuhan Corporation
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公开(公告)号：EP4403218A3
公开(公告)日：2024-11-06
申请号：EP24170761.1
申请日：2018-12-14
申请人： ABL Bio, Inc.
发明人： AHN, Jinhyung , AN, Sungwon , KIM, Dongin , SUNG, Eunsil , EOM, Jaehyun , LEE, Sang Hoon , YOU, Weonkyoo , KIM, Juhee , PARK, Kyungjin , CHUNG, Hyejin , JUNG, Jinwon , LEE, Bora , SUNG, Byungje , KIM, Yeunju , SON, Yong-Gyu , AHN, Seawon , SONG, Daehae , YOO, Jiseon , PAK, Youngdon , YEOM, Donghoon , LEE, Yoseob , JUNG, Jaeho
摘要： The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and use of the bi-specific antibody for treating or diagnosing synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates. The IGF1R portion of the bi-specific antibody acts as a shuttle to penetrate the blood brain barrier, allowing the alpha-synuclein portion to exert its action in the brain. Further, the half-life of the bi-specific antibody may be extended to maintain efficacy over time.
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公开(公告)号：EP3797124A1
公开(公告)日：2021-03-31
申请号：EP19806701.9
申请日：2019-05-23
申请人： ABL Bio Inc.
发明人： LEE, Yangsoon , KIM, Juhee , PARK, Kyungjin , YEOM, Donghoon , PARK, Kyeongsu , CHUNG, Hyejin , KIM, Yeunju , PARK, Eunyoung , JUNG, Uijung , SUNG, Eunsil , AHN, Jinhyung , SUNG, Byungje , SONG, Daehae , PAK, Youngdon
IPC分类号： C07K16/28 , C07K16/40 , A61K47/68 , A61P35/00 , G01N33/574
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公开(公告)号：EP4373856A1
公开(公告)日：2024-05-29
申请号：EP22845538.2
申请日：2022-07-20
申请人： ABL Bio Inc.
发明人： SUNG, Eunsil , KWON, Junga , KIM, Youngkwang , KIM, Juhee , PARK, Kyungjin , PARK, Sumyeong , SUNG, Byungje , YOO, Byeongmin , LEE, Bora , LEE, Suyoun , LEE, Shinai , LEE, Yangsoon , LEE, Eunhee , LIM, Yangmi , JEON, Jaehyoung , JUNG, Jinwon
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公开(公告)号：EP3853257A1
公开(公告)日：2021-07-28
申请号：EP20851985.0
申请日：2020-08-12
发明人： JIANG, Wenqing , FANG, Lei , WANG, Zhengyi , GUO, Bingshi , PARK, Eunyoung , SUNG, Eunsil , SUNG, Byungje
IPC分类号： C07K16/28 , C12N15/13 , A61K39/395 , A61P35/00
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公开(公告)号：EP3891187A1
公开(公告)日：2021-10-13
申请号：EP19890398.1
申请日：2019-02-15
发明人： PARK, Eunyoung , LEE, Yangsoon , CHUNG, Hyejin , SUNG, Eunsil , YOO, Jiseon , PARK, Minji , SON, Yong-Gyu , CHOI, Hyoju , KIM, Eunjung , JUNG, Jaeho , YOU, Weon-Kyoo , LEE, Sang Hoon , FANG, Lei , JIANG, Wenqing
IPC分类号： C07K16/46 , C12N15/13 , A61K39/395 , A61P35/00
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公开(公告)号：EP3802612A1
公开(公告)日：2021-04-14
申请号：EP19807093.0
申请日：2019-05-24
申请人： ABL Bio Inc.
发明人： PARK, Kyeongsu , LEE, Yangsoon , CHUNG, Hyejin , JUNG, Uijung , SON, Yong-Gyu , HA, Sang-Jun , KIM, Myeong Joon , PARK, Eunyoung , PARK, Kyungjin , SUNG, Eunsil , KIM, Yeunju , AHN, Jinhyung , SUNG, Byungje , SONG, Daehae , PAK, Youngdon
IPC分类号： C07K16/28 , A61K47/68 , A61P35/00 , G01N33/574 , A61K39/00
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公开(公告)号：EP3725806A1
公开(公告)日：2020-10-21
申请号：EP18889608.8
申请日：2018-12-14
申请人： ABL Bio Inc.
发明人： AHN, Jinhyung , AN, Sungwon , KIM, Dongin , SUNG, Eunsil , EOM, Jaehyun , LEE, Sang Hoon , YOU, Weonkyoo , KIM, Juhee , PARK, Kyungjin , CHUNG, Hyejin , JUNG, Jinwon , LEE, Bora , SUNG, Byungje , KIM, Yeunju , SON, Yong-gyu , AHN, Seawon , SONG, Daehae , YOO, Jiseon , PAK, Youngdon , YEOM, Donghoon , LEE, Yoseob , JUNG, Jaeho
摘要： The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bi-specific antibody for the prevention, treatment and / or diagnosis of synucleinopatheis associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.
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