Systems and methods 500 for providing an efficient and configurable port interface in an avionics data transfer system 100 are provided. For instance, in one embodiment a set of virtual ports associated with an avionics data transfer system 100 can be defined. At least as a subset of the virtual ports can be mapped to one or more addresses 402 in a memory space associated with the data transfer system 100, such that each virtual port has a fixed definition in the memory space. One or more of the virtual ports can then be associated with one or more physical ports 308 associated with an interface between a host computing device 202 and an end system 200 in the data transfer system 100 by specifying for the one or more virtual ports a plurality of port parameters that define the respective one or more physical ports 308.