- 专利标题： PYRIDINE DERIVATIVE AND USE THEREOF
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申请号： EP22872006.6申请日： 2022-09-21
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公开(公告)号： EP4406948A1公开(公告)日： 2024-07-31
- 发明人: CHEN, Shoujun , QIANG, Xiaoming , DING, Zhao , XIONG, Yong , WANG, Haibo , LIU, Ke , LIU, Mingdeng
- 申请人： Sichuan Huiyu Pharmaceutical Co., Ltd. , Sichuan Huiyu Seacross Pharmaceutical Technology Co., Ltd.
- 申请人地址： CN Neijiang, Sichuan 641000 Building 3 No.333, Hanyang Road Shizhong District
- 专利权人： Sichuan Huiyu Pharmaceutical Co., Ltd.,Sichuan Huiyu Seacross Pharmaceutical Technology Co., Ltd.
- 当前专利权人： Sichuan Huiyu Pharmaceutical Co., Ltd.,Sichuan Huiyu Seacross Pharmaceutical Technology Co., Ltd.
- 当前专利权人地址： CN Neijiang, Sichuan 641000 Building 3 No.333, Hanyang Road Shizhong District
- 代理机构： Huang, Liwei
- 优先权： CN 2111108176 2021.09.22
- 国际申请： CN2022120154 2022.09.21
- 国际公布： WO2023045960 2023.03.30
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D239/72 ; C07D471/04 ; C07D403/14 ; A61K31/517 ; A61P35/00
摘要：
A pyridine derivative and use thereof. The compound has an obvious inhibitory effect on the activity of KRAS and PI3K proteins, can be used as a KRAS and/or PI3K protein inhibitor, and can be used for preparing a drug for treatment of diseases such as KRAS or PI3K protein-mediated cancer. The compound has an extremely strong inhibitory effect on a KRAS G12C inhibitor (e.g. AMG-510) drug-resistant cancer cells , and has a wide application prospect thereof.
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