公开(公告)号：EP4406948A1

公开(公告)日：2024-07-31

申请号：EP22872006.6

申请日：2022-09-21

申请人： Sichuan Huiyu Pharmaceutical Co., Ltd. ,  Sichuan Huiyu Seacross Pharmaceutical Technology Co., Ltd.

发明人： CHEN, Shoujun ,  QIANG, Xiaoming ,  DING, Zhao ,  XIONG, Yong ,  WANG, Haibo ,  LIU, Ke ,  LIU, Mingdeng

IPC分类号： C07D401/14 ,  C07D239/72 ,  C07D471/04 ,  C07D403/14 ,  A61K31/517 ,  A61P35/00

CPC分类号： A61K31/517 ,  A61P35/00 ,  C07D239/72 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04

摘要： A pyridine derivative and use thereof. The compound has an obvious inhibitory effect on the activity of KRAS and PI3K proteins, can be used as a KRAS and/or PI3K protein inhibitor, and can be used for preparing a drug for treatment of diseases such as KRAS or PI3K protein-mediated cancer. The compound has an extremely strong inhibitory effect on a KRAS G12C inhibitor (e.g. AMG-510) drug-resistant cancer cells , and has a wide application prospect thereof.