- 专利标题： DERIVATIVE OF ASPARTIC ACID AND USE THEREOF IN TREATMENT OF METABOLIC DISEASES SUCH AS HEPATIC FIBROSIS AND NON-ALCOHOLIC HEPATITIS
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申请号： EP22892084.9申请日： 2022-11-11
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公开(公告)号： EP4446307A1公开(公告)日： 2024-10-16
- 发明人: GAO, Jie , CHENG, Huimin , CHENG, Jun , ZHANG, Peiyu
- 申请人： SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
- 申请人地址： CN Shenzhen Guangdong 518017 Floor 3, 289 Digitland, No. 2 Hongliu Road Fubao Community, Fubao Street, Futian District
- 代理机构： Kluin Patent
- 优先权： CN202210661248 20220613
- 国际公布： WO2023083291 20230519
- 主分类号： C07C219/08
- IPC分类号： C07C219/08 ; C07K5/062 ; A61K31/223 ; A61P1/06
摘要：
The present invention relates to compounds of Formula I and Formula II and the use thereof in the treatment of metabolic diseases such as liver fibrosis and non-alcoholic hepatitis. Specifically, provided are the compounds as shown, and pharmaceutically acceptable salts or esters, prodrug, stereoisomers, hydrates, solvates, crystalline forms and metabolite forms thereof, or any combination or mixture thereof in the preparation of a drug or reagent, the drug being used for at least one of the following: A-(L 1 ) x -A' (Formula I); A 1 -(L 1 ) x -A 1 ' (Formula II).
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