发明专利
JP2005040134A 3-phosphoglycerate dehydrogenase variant whose inhibition by l-serine is reduced, and gene encoding them and use of the same
有权
由L-丝氨酸抑制的3-磷酸脱氢酶脱氢酶的变异及其编码及其使用的基因
- 专利标题: 3-phosphoglycerate dehydrogenase variant whose inhibition by l-serine is reduced, and gene encoding them and use of the same
- 专利标题(中): 由L-丝氨酸抑制的3-磷酸脱氢酶脱氢酶的变异及其编码及其使用的基因
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申请号: JP2004205113申请日: 2004-07-12
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公开(公告)号: JP2005040134A公开(公告)日: 2005-02-17
- 发明人: MAYER THOMAS , FLINSPACH RENATE
- 申请人: Consortium Elektrochem Ind Gmbh , コンゾルテイウム フユール エレクトロケミツシエ インヅストリー ゲゼルシヤフト ミツト ベシユレンクテル ハフツング
- 专利权人: Consortium Elektrochem Ind Gmbh,コンゾルテイウム フユール エレクトロケミツシエ インヅストリー ゲゼルシヤフト ミツト ベシユレンクテル ハフツング
- 当前专利权人: Consortium Elektrochem Ind Gmbh,コンゾルテイウム フユール エレクトロケミツシエ インヅストリー ゲゼルシヤフト ミツト ベシユレンクテル ハフツング
- 优先权: DE10331291 2003-07-10
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12N9/04 ; C12N15/53 ; C12P13/04 ; C12P13/06
摘要:
PROBLEM TO BE SOLVED: To provide an Escherichia coli PGD variant having a reduced susceptibility to inhibition by serine compared with Escherichia coli wild-type. SOLUTION: This object is achieved by means of a PGD which has an amino acid sequence which differs from the amino acid sequence of the Escherichia coli wild-type PGD (comprising a specific sequence) having a methionine as position 1, in that an amino acid apart from glycine is present at position 349 or an amino acid apart from threonine is present at position 372. COPYRIGHT: (C)2005,JPO&NCIPI
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