发明专利
JP2008253251A Nucleic acid analog, diagnostic agent and method for using the same in analysis method
审中-公开
核酸类似物,诊断试剂及其在分析方法中的使用方法
- 专利标题: Nucleic acid analog, diagnostic agent and method for using the same in analysis method
- 专利标题(中): 核酸类似物,诊断试剂及其在分析方法中的使用方法
-
申请号: JP2008060342申请日: 2008-03-10
-
公开(公告)号: JP2008253251A公开(公告)日: 2008-10-23
- 发明人: BUCHARDT OLE , EGHOLM MICHAEL , NIELSEN PETER EIGIL , BERG ROLF HENRIK
- 申请人: Rolf Henrik Berg , Buchardt Dorte , Michael Egholm , Peter Eigil Nielsen , エグホルム、ミカエル , ニールセン、ピーター・アイギル , ブカルト、ドルテ , ベルク、ロルフ・ヘンリク
- 专利权人: Rolf Henrik Berg,Buchardt Dorte,Michael Egholm,Peter Eigil Nielsen,エグホルム、ミカエル,ニールセン、ピーター・アイギル,ブカルト、ドルテ,ベルク、ロルフ・ヘンリク
- 当前专利权人: Rolf Henrik Berg,Buchardt Dorte,Michael Egholm,Peter Eigil Nielsen,エグホルム、ミカエル,ニールセン、ピーター・アイギル,ブカルト、ドルテ,ベルク、ロルフ・ヘンリク
- 优先权: DK98691 1991-05-24; DK98791 1991-05-24; DK51092 1992-04-15
- 主分类号: A61K31/70
- IPC分类号: A61K31/70 ; C12N15/09 ; A61K38/00 ; A61K48/00 ; A61P31/12 ; A61P43/00 ; C07D519/00 ; C07H21/00 ; C07H21/04 ; C07K1/22 ; C07K5/06 ; C07K5/078 ; C07K5/08 ; C07K5/10 ; C07K7/06 ; C07K7/08 ; C07K9/00 ; C07K14/00 ; C07K16/00 ; C08G69/00 ; C12Q1/68 ; G01N33/53
摘要:
PROBLEM TO BE SOLVED: To provide a nucleic acid analog for performing capture, recognition, detection, identification or quantification about chemically or microbiologically individual units. SOLUTION: The nucleic acid analogues provided are: (a) a PNA (peptide nucleic acid) including a polyamide backbone bearing a plurality of ligands at respective spaced locations along the backbone, where each ligand being bound directly or indirectly to a nitrogen atom in the backbone and the ligand bearing nitrogen atoms mainly being separated from one another in the backbone by 4-8 intervening atoms; (b) a nucleic acid analog capable of hybridizing to a nucleic acid of complementary sequence to form a hybrid which is more stable against denaturation by heat than a hybrid between the conventional deoxyribonucleotide and the nucleic acid; or (c) a nucleic acid analogue capable of hybridizing to double-stranded nucleic acid in which one strand has a sequence complementary to the analogue, so as to displace the other strand from one strand. COPYRIGHT: (C)2009,JPO&INPIT
信息查询